The isoperfluoropropyl group (i-C3F7) is an analogue of the trifluoromethyl group (CF3) featuring a stronger electron-withdrawing effect and more steric hindrance, giving it a unique role in synthetic chemistry, however, direct isoperfluoropropylation remains challenging. Here, the authors develop a highly reactive electrophilic hypervalent-iodine based i-C3F7 reagent and demonstrate its use for the efficient isoperfluoropropylation of aromatic C–H bonds.
- Yaxing Wu
- Yunchen Jiang
- Chao Chen
