Nature Search

A common subcortical oscillatory network contributes to recovery after spinal cord injury

Yukio Nishimura
Yosuke Morichika
Tadashi Isa
ResearchOpen Access03 Jun 2008
Nature Precedings

P: 1
Carotenoids bind rhodopsins and act as photocycle-accelerating pigments in marine Bacteroidota

In marine bacteria, carotenoids enhance rhodopsin function by acting as light-harvesting antennae and photocycle-accelerating pigments, a dual mechanism that enhances light energy capture and expands the known strategies of microbial phototrophy.

Takayoshi Fujiwara
Toshiaki Hosaka
Susumu Yoshizawa
Research04 Sept 2025
Nature Microbiology

Volume: 10, P: 2603-2615
Eosinophils as a predictive marker of treatment-related adverse events in mRCC patients treated with first-line immune-checkpoint inhibitor combination therapy

Tatsushi Kawada
Satoshi Katayama
Motoo Araki
ResearchOpen Access25 Jul 2025
Scientific Reports

Volume: 15, P: 1-8
Deciphering state-dependent immune features from multi-layer omics data at single-cell resolution

A single-cell multiomic immune cell atlas from 235 Japanese, including patients with COVID-19 and healthy individuals, linked with host genetics including germline and somatic mutation, plasma proteomics and metagenomics data reveals that immune cells are dynamically regulated in a cell state-dependent manner.

Ryuya Edahiro
Go Sato
Yukinori Okada
ResearchOpen Access28 Jul 2025
Nature Genetics

Volume: 57, P: 1905-1921
Synthesis of Polyesters Containing the [60]Fullerene Moiety in the Main Chain

Masumi Taki
Shoji Takigami
Jun Nishimura
Research01 Dec 1997
Polymer Journal

Volume: 29, P: 1020-1022
Genome sequencing provides high diagnostic yield and new etiological insights for intellectual disability and developmental delay

Kohei Hamanaka
Atsushi Fujita
Naomichi Matsumoto
ResearchOpen Access26 Aug 2025
npj Genomic Medicine

Volume: 10, P: 1-12
Blood DNA virome associates with autoimmune diseases and COVID-19

Analysis of the blood DNA virome in patients with COVID-19 and autoimmune disease associates endogenous HHV-6 (eHHV-6) and high anellovirus load with increased disease risk, most notably for systemic lupus erythematosus. eHHV-6 carriers show a distinct immune response.

Noah Sasa
Shohei Kojima
Yukinori Okada
ResearchOpen Access03 Jan 2025
Nature Genetics

Volume: 57, P: 65-79
iTRAQ-based quantitative proteomics reveals reduced expression of KRT19, KRT7, and PSTDG in cutaneous specimens after kidney transplantation

Ichiro Tsuboi
Yosuke Mitsui
Motoo Araki
ResearchOpen Access26 Sept 2025
Scientific Reports

Volume: 15, P: 1-16
The efficacy and safety of FOLFOX therapy for advanced esophageal squamous cell carcinoma

Kazuhiro Shiraishi
Mao Okada
Kenro Hirata
ResearchOpen Access07 Mar 2025
Scientific Reports

Volume: 15, P: 1-9
The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force

Genetic mechanisms influencing COVID-19 susceptibility are not well understood. Here, the authors analyzed whole blood RNA-seq data of 465 Japanese individuals with COVID-19, highlighting thousands of fine-mapped variants affecting expression and splicing of genes, as well as the presence of COVID-19 severity-interaction eQTLs.

Qingbo S. Wang
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access22 Aug 2022
Nature Communications

Volume: 13, P: 1-19
DOCK2 is involved in the host genetics and biology of severe COVID-19

A genome-wide association study highlights a variant in DOCK2, which is common in East Asian populations but rare in Europeans, as a host genetic risk factor for severe COVID-19.

Ho Namkoong
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access08 Aug 2022
Nature

Volume: 609, P: 754-760
Double-stranded RNA sequencing reveals distinct riboviruses associated with thermoacidophilic bacteria from hot springs in Japan

Prokaryotic RNA viruses recovered from hot springs in Japan using fragmented and primer-ligated dsRNA sequencing form divergent clades in the Riboviria branch of RNA viruses.

Syun-ichi Urayama
Akihito Fukudome
Takuro Nunoura
ResearchOpen Access17 Jan 2024
Nature Microbiology

Volume: 9, P: 514-523
Multi-omics analysis defines highly refractory RAS burdened immature subgroup of infant acute lymphoblastic leukemia

The molecular heterogeneity of KMT2A-rearranged infant acute lymphoblastic leukemia (ALL) remains poorly characterised. Here, the authors perform multi-omics analysis for 84 ALL patients and suggest 5 distinct subgroups for risk stratification and personalised treatment.’

Tomoya Isobe
Masatoshi Takagi
Junko Takita
ResearchOpen Access30 Aug 2022
Nature Communications

Volume: 13, P: 1-16
Mutant ASXL1 induces age-related expansion of phenotypic hematopoietic stem cells through activation of Akt/mTOR pathway

ASXL1 mutations are frequently found in age-related clonal haemaotopoiesis (CH), but how they drive CH is unclear. Here the authors show that expression of C-terminal truncated ASXL1 in haematopoietic stem cells (HSCs) leads to Akt de-ubiquitination, activated Akt/mTOR signaling, and aberrant HSC proliferation.

Takeshi Fujino
Susumu Goyama
Toshio Kitamura
ResearchOpen Access23 Mar 2021
Nature Communications

Volume: 12, P: 1-20
Single-cell analyses and host genetics highlight the role of innate immune cells in COVID-19 severity

Peripheral blood mononuclear cells from 73 Japanese patients with coronavirus disease 2019 (COVID-19) and 75 healthy controls were analyzed using single-cell transcriptomics. Combining these data with genotyping data highlights the interplay between host genetics and the immune response in modulating disease severity.

Ryuya Edahiro
Yuya Shirai
Yukinori Okada
ResearchOpen Access24 Apr 2023
Nature Genetics

Volume: 55, P: 753-767
Identification and replication of sex-dimorphic protein quantitative trait loci across multiple ancestries and their associations with diseases

Youngjune Bhak
Vasilis Raptis
Albert Tenesa
ResearchOpen Access28 Aug 2025
Scientific Reports

Volume: 15, P: 1-16
Novel rare variations in genes that regulate developmental change in N-methyl-d-aspartate receptor in patients with schizophrenia

Akane Yoshikawa
Fumichika Nishimura
Chihiro Kakiuchi
ResearchOpen Access01 Feb 2018
Human Genome Variation

Volume: 5, P: 1-5
Effects of Citrin Deficiency in the Perinatal Period: Feasibility of Newborn Mass Screening for Citrin Deficiency

Akiko Tamamori
Akie Fujimoto
Tsunekazu Yamano
Research01 Oct 2004
Pediatric Research

Volume: 56, P: 608-614
Correction: Distribution and survival strategies of endemic and cosmopolitan diazotrophs in the Arctic Ocean

Takuhei Shiozaki
Yosuke Nishimura
Naomi Harada
Amendments and CorrectionsOpen Access01 Jun 2023
The ISME Journal

Volume: 17, P: 1351
Comparative analysis of necrotizing enterocolitis in preterm infants born in Japan and born to mothers of Japanese ethnicity in California

Satoshi Kusuda
Mihoko V. Bennett
Asao Yara
ResearchOpen Access22 Mar 2025
Scientific Reports

Volume: 15, P: 1-11
Longitudinal assessment of health-related quality of life in Japanese patients with advanced urothelial carcinoma receiving immune check point inhibitors

Makito Miyake
Nobutaka Nishimura
Kiyohide Fujimoto
ResearchOpen Access04 Oct 2024
Scientific Reports

Volume: 14, P: 1-11
Identification and functional characterization of the extremely long allele of the serotonin transporter-linked polymorphic region

Tempei Ikegame
Yosuke Hidaka
Kazuya Iwamoto
ResearchOpen Access11 Feb 2021
Translational Psychiatry

Volume: 11, P: 1-7
Rescue-like Behaviour in Mice is Mediated by Their Interest in the Restraint Tool

Hiroshi Ueno
Shunsuke Suemitsu
Takeshi Ishihara
ResearchOpen Access02 Aug 2019
Scientific Reports

Volume: 9, P: 1-10
Distribution and survival strategies of endemic and cosmopolitan diazotrophs in the Arctic Ocean

Takuhei Shiozaki
Yosuke Nishimura
Naomi Harada
ResearchOpen Access23 May 2023
The ISME Journal

Volume: 17, P: 1340-1350
Locality and diel cycling of viral production revealed by a 24 h time course cross-omics analysis in a coastal region of Japan

Takashi Yoshida
Yosuke Nishimura
Hiroyuki Ogata
ResearchOpen Access30 Jan 2018
The ISME Journal

Volume: 12, P: 1287-1295
A unique clade of light-driven proton-pumping rhodopsins evolved in the cyanobacterial lineage

Masumi Hasegawa
Toshiaki Hosaka
Susumu Yoshizawa
ResearchOpen Access07 Oct 2020
Scientific Reports

Volume: 10, P: 1-10
Altered expression of microRNA-223 in the plasma of patients with first-episode schizophrenia and its possible relation to neuronal migration-related genes

Zhilei Zhao
Seiichiro Jinde
Kiyoto Kasai
ResearchOpen Access11 Nov 2019
Translational Psychiatry

Volume: 9, P: 1-11
A blue-shifted anion channelrhodopsin from the Colpodellida alga Vitrella brassicaformis

Keiichi Kojima
Shiho Kawanishi
Yuki Sudo
ResearchOpen Access28 Apr 2023
Scientific Reports

Volume: 13, P: 1-11
Two novel mutations of COMP in Japanese boys with pseudoachondroplasia

Yosuke Ichihashi
Masaki Takagi
Tomonobu Hasegawa
ResearchOpen Access08 Jun 2018
Human Genome Variation

Volume: 5, P: 1-3
Development of a New Enzymatic Diagnosis Method for Very-long-chain Acyl-CoA Dehydrogenase Deficiency by Detecting 2-Hexadecenoyl-CoA Production and its Application in Tandem Mass Spectrometry-based Selective Screening and Newborn Screening in Japan

Go Tajima
Nobuo Sakura
Masao Kobayashi
Research01 Dec 2008
Pediatric Research

Volume: 64, P: 667-672
Deletion of podocyte Rho-associated, coiled-coil-containing protein kinase 2 protects mice from focal segmental glomerulosclerosis

ROCK2 activation in podocytes contributes to FSGS. Disrupting ROCK2 in podocytes protects against damage, highlighting its potential as a therapeutic target.

Keiichiro Matoba
Yosuke Nagai
Rimei Nishimura
ResearchOpen Access02 Apr 2024
Communications Biology

Volume: 7, P: 1-9
Correction: Locality and diel cycling of viral production revealed by a 24 h time course cross-omics analysis in a coastal region of Japan

Takashi Yoshida
Yosuke Nishimura
Hiroyuki Ogata
Amendments and CorrectionsOpen Access01 Aug 2018
The ISME Journal

Volume: 12, P: 3046
POGLUT1, the putative effector gene driven by rs2293370 in primary biliary cholangitis susceptibility locus chromosome 3q13.33

Yuki Hitomi
Kazuko Ueno
Minoru Nakamura
ResearchOpen Access14 Jan 2019
Scientific Reports

Volume: 9, P: 1-11
NELFCD and CTSZ loci are associated with jaundice-stage progression in primary biliary cholangitis in the Japanese population

Nao Nishida
Yoshihiro Aiba
Minoru Nakamura
ResearchOpen Access23 May 2018
Scientific Reports

Volume: 8, P: 1-9
ROCK2-induced metabolic rewiring in diabetic podocytopathy

ROCK2 is found to be activated in 3 diabetic models and patients with diabetes. ROCK2 deletion in podocytes protects against diabetic kidney injury, with the beneficial effect of ROCK2 inhibition observed due to rescued PPARα signaling, leading to a recovery of fatty acid metabolism.

Keiichiro Matoba
Yusuke Takeda
Rimei Nishimura
ResearchOpen Access08 Apr 2022
Communications Biology

Volume: 5, P: 1-9
Genetic profiles of Barrett’s esophagus and esophageal adenocarcinoma in Japanese patients

Mamoru Tokunaga
Kenichiro Okimoto
Naoya Kato
ResearchOpen Access03 Sept 2021
Scientific Reports

Volume: 11, P: 1-11
A biodegradable microneedle sheet for intracorporeal topical hemostasis

Mao Yokoyama
Namie Chihara
Nobuhiro Kato
ResearchOpen Access02 Nov 2020
Scientific Reports

Volume: 10, P: 1-10
Correlates of neutralizing/SARS-CoV-2-S1-binding antibody response with adverse effects and immune kinetics in BNT162b2-vaccinated individuals

Kenji Maeda
Masayuki Amano
Hiroaki Mitsuya
ResearchOpen Access24 Nov 2021
Scientific Reports

Volume: 11, P: 1-10
Distal arthrogryposis in a girl arising from a novel TNNI2 variant inherited from paternal somatic mosaicism

Rie Seyama
Yuri Uchiyama
Naomichi Matsumoto
Research12 Jan 2023
Journal of Human Genetics

Volume: 68, P: 363-367
Interferon-gamma improves impaired dentinogenic and immunosuppressive functions of irreversible pulpitis-derived human dental pulp stem cells

Soichiro Sonoda
Haruyoshi Yamaza
Takayoshi Yamaza
ResearchOpen Access18 Jan 2016
Scientific Reports

Volume: 6, P: 1-12
The OceanDNA MAG catalog contains over 50,000 prokaryotic genomes originated from various marine environments

Yosuke Nishimura
Susumu Yoshizawa
ResearchOpen Access17 Jun 2022
Scientific Data

Volume: 9, P: 1-11
Decreased proteasomal function accelerates cigarette smoke-induced pulmonary emphysema in mice

Yosuke Yamada
Utano Tomaru
Masanori Kasahara
Research27 Apr 2015
Laboratory Investigation

Volume: 95, P: 625-634

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