We report methacrylated silk fibroin sealant (Sil-MAS) with rapid crosslinkable, highly adhesive and biocompatible properties and demonstrate its versatility as medical glue. The excellence for physical properties of Sil-MAS is revealed via in vitro mechanical tests and ex vivo aorta pressure test. In in vivo biological tests on skin, liver, and blood vessels of rat, Sil-MAS showed a superb hemostatic and adhesive ability with high biocompatibility. Specifically, Sil-MAS strongly contributed to fast wound healing. Furthermore, we showed that Sil-MAS could be an ideal photocuring laparoscopic medical glue in laceration rabbit model of liver and stomach serosa using self-made endoscopic device.
- Soon Hee Kim
- Young Jin Lee
- Chan Hum Park