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A nanoparticle-based microfluidic assay enables rapid sterility testing of biopharmaceuticals, such as those derived from human mesenchymal stem cells and T cells, by detecting microbial contamination within 18 h.

Implantable energy devices must ensure biocompatibility and electrochemical safety. Here, the authors present a fiber-based supercapacitor with high durability and flexibility, enabling seamless implantation and reliable long-term operation.

The limited operational stability of multi-resonance thermally activated delayed fluorescence emitters often constrains their practical application. Here, the authors report a direct correlation between device lifetime and Faradaic yield for oxidative degradation of emitter molecules.

Hepatic stellate cells regulate hepatocyte functions via R-spondin 3.

Charge order has been typically reported in doped systems with high d-electron occupancy. Here the authors demonstrate a charge-ordered insulating state in a La-doped SrTiO₃ epitaxial film which has the lowest d-electron occupancy and attribute it to surface distortion that favours electron-phonon coupling.

Developing photoredox catalysts with long-lived excited states that feature highly cathodic oxidation potentials is imperative. Here, the authors demonstrate the C–C cross-coupling catalytic utility of two-coordinate LLCT-active Au(I) complex photocatalysts with visible-light absorption and a 210 ns-long excited-state lifetime.

An analysis of gut microbiomes of patients with non-small-cell lung cancer reveals an association between Bifidobacterium bifidum abundance and response to cancer therapy. In murine models of syngeneic tumours, administration of commercial B. bifidum strains synergizes with immune checkpoint blockade to reduce tumour burden, but the therapeutic potential of B. bifidum is affected by strain-level variation.

A wearable microgrid powered solely by fingertip perspiration can monitor metabolic biomarkers over extended periods of time.

Soluble catalysts such as redox mediators are promising in enhancing energy efficiency of Li–O₂ batteries. Here, the authors propose a design principle for finding efficient redox mediators and demonstrate the application of such a new catalyst.

The limit external quantum efficiency of organic LEDs based on isotropically oriented iridium complexes is believed to be around 30%. But Kim et al. show that the emission from these complexes is in fact anisotropic, enabling them to increase the external quantum efficiency of these devices to 36%.

Lithium-rich layered oxides, promising high-energy-density cathode materials, face electrochemical degradation due to structural disordering. Here, the authors report that slab gliding is a key trigger of this disordering and a pivotal unexplored avenue for a reversible anionic redox reaction.

Baek and colleagues present a proteogenomic analysis of 196 patients with pancreatic adenocarcinoma in an Asian population, identifying subtypes with invasive and proliferative features or immunogenic features, as a resource for future studies.

Zhang et al. identify and characterize supermeres as extracellular nanoparticles that exhibit unique biological and functional properties with potential prognostic and therapeutic value across distinct diseases.

This work introduces a photolithographic process to form micrometer-scale organic RGB pixel patterns based on molecular crosslinking strategy. The method can be utilized for achieving high-resolution full-color OLEDs.

The use of membranes under harsh conditions, particularly involving the separation of complex organic solvents, remains challenging. Here the authors demonstrate an ultrathin organosiloxane polymer membrane using initiated chemical vapor deposition to effectively separate solutes within the molecular weight range of 150–300 g mol⁻¹.

Commercial electrolytes for lithium ion batteries cannot be used for current metal-gas batteries due to the instability despite various merits. Here, the authors successfully exploit a widely used carbonate-based electrolyte to boost the electrochemical performance of lithium-sulfur dioxide batteries for the first time.

Transition metal oxide electrodes are promising for rechargeable batteries but are subject to suffer from structural transformations and electrochemical degradation. The evolution of oxygen-redox activity and reversibility in layered electrodes are shown to arise from cation-migration mechanisms during de/intercalation.

New dopant and host materials yield a deep blue phosphorescent organic light-emitting diode with a lifetime exceeding 1,000 h.

Increased levels of the Yap oncoprotein stimulate liver growth and promote hepatocarcinogenesis. Here the authors show that hepatocyte-specific loss of Atg7 in mice leads to decreased autophagic degradation of Yap and liver overgrowth, and further establish this association in human liver cancer tissues.

Efficient statistical emulation of melting land ice under various climate scenarios to 2100 indicates a contribution from melting land ice to sea level increase of at least 13 centimetres sea level equivalent.

Gallbladder cancer incidence shows characteristic geographic patterns. Here the authors perform a genomic analysis of gallbladder cancers in patients from countries with high incidence (South Korea, India and Chile) and identify ELF3 and other significantly mutated genes not previously associated with gallbladder cancer.

The glass transition temperature (Tg) is a key property that dictates the applicability of conjugated polymers. Here the authors use one adjustable parameter to build a relationship between the Tg and the molecular structure of semiflexible polymers that differ in aromatic backbone and alkyl side chain chemistry.

CsPbI₃ perovskite solar cells have potential for tandem applications but are sensitive to moisture. Here, CsPbI₃ cells under high humidity were fabricated using dimethylammonium iodide volatilization for precise annealing and 1,8-diaminooctane passivation to enhance efficiency and stability, achieving 17.7% efficiency.

Direct stimulation of the focus of a seizure may have potential for the treatment of epilepsy. Here the authors demonstrate in a rat model a sequential narrow-field stimulation method for terminating seizures.

Kim et al. show that several Streptococcus species improve the structure and barrier function of human skin. They find that Streptococcus-secreted spermidine accelerates the recovery of skin structure and barrier function by increasing collagen and lipid synthesis in aged cells. This study suggests the role of skin microbiome for anti-aging.