Joseph Angeloni et al. show that Caenorhabditis elegans can detect and are attracted to multiple signal molecules produced by the bacterium Vibrio cholerae, specifically the 3′,5′-cyclic diguanylate (c-di-GMP), even though this bacterium kills the host at a high rate. This study reveals how bacterial c-di-GMP may serve as a cue for C. elegans that they can use to detect food or alternatively, impair their immune response, which could facilitate bacterial invasion and survival.
- Joseph Angeloni
- Yuqing Dong
- Min Cao
