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Scientific Reports (29)
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Showing 1–50 of 85 results

Advanced filters: Author: Yusuke Imai Clear advanced filters

Thermoresponsive Organic–Inorganic Polymer Hybrids from Poly(N-isopropylacrylamide)

Yusuke Imai
Naoki Yoshida
Yoshiki Chujo
Research01 Mar 1999
Polymer Journal

Volume: 31, P: 258-262
Molecular basis of potent antiviral HLA-C-restricted CD8⁺ T cell response to an immunodominant SARS-CoV-2 nucleocapsid epitope

Cytotoxic T lymphocytes targeting ancestral SARS-CoV-2 recognise variants of concern, but deep molecular understanding of why these responses are conserved is hampered by the populational variability due to HLA-restriction. Here authors identify an HLA-C-restricted conserved immunodominant SARS-CoV-2 nucleocapsid epitope in COVID-19 convalescent donors from early waves of the pandemic and provide structural bases for its recognition by the T cell receptor.

Yoshihiko Goto
You Min Ahn
Chihiro Motozono
ResearchOpen Access28 Aug 2025
Nature Communications

Volume: 16, P: 1-18
Properties of Poly(ethylene terephthalate)/Layered Silicate Nanocomposites Prepared by Two-Step Polymerization Procedure

Yusuke Imai
Yoshinari Inukai
Hiroshi Tateyama
Research01 Mar 2003
Polymer Journal

Volume: 35, P: 230-235
Isolation and characterization of a human cDNA encoding a protein homologous to the 7.2-kDa protein (subunit X) of bovine ubiquinol-cytochrome C reductase

H. Akashi
H-J. Han
Y. Nakamura
Research01 Jan 2000
Journal of Human Genetics

Volume: 45, P: 43-46
Identification by differential display of eight known genes induced during in vivo intimal hyperplasia

Makoto Itoh
Shuichi Tsukada
Toshihiro Tanaka
Research01 Feb 1998
Journal of Human Genetics

Volume: 43, P: 9-13
Involvement of cigarette smoke-induced epithelial cell ferroptosis in COPD pathogenesis

Altered iron homeostasis resulting in excessive oxidative stress has been implicated in smoke-induced lung diseases. Here the authors show that ferroptosis of lung epithelial cells, potentially resulting from excessive ferritinophagy, is involved in the pathogenesis of COPD.

Masahiro Yoshida
Shunsuke Minagawa
Kazuyoshi Kuwano
ResearchOpen Access17 Jul 2019
Nature Communications

Volume: 10, P: 1-14
Reversible Formation of Interpenetrating Polymer Network Structure in Organic-Inorganic Polymer Hybrids

Yusuke Imai
Kensuke Naka
Yoshiki Chujo
Research01 Dec 1998
Polymer Journal

Volume: 30, P: 990-995
DOCK2 is involved in the host genetics and biology of severe COVID-19

A genome-wide association study highlights a variant in DOCK2, which is common in East Asian populations but rare in Europeans, as a host genetic risk factor for severe COVID-19.

Ho Namkoong
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access08 Aug 2022
Nature

Volume: 609, P: 754-760
Integrated molecular analysis of adult T cell leukemia/lymphoma

Seishi Ogawa and colleagues report the results of a large-scale sequencing study of adult T cell leukemia/lymphoma. They find recurrent alterations enriched for T cell receptor/NF-κB signaling, T cell trafficking and other T cell pathways and highlight targets for the development of new therapeutics for this intractable cancer.

Keisuke Kataoka
Yasunobu Nagata
Seishi Ogawa
Research05 Oct 2015
Nature Genetics

Volume: 47, P: 1304-1315
Enhanced fusogenicity and pathogenicity of SARS-CoV-2 Delta P681R mutation

The P681R mutation in the spike protein renders the Delta variant more pathogenic than prototypic SARS-CoV-2 in infected hamsters, and facilitates spike protein cleavage and enhances viral fusogenicity.

Akatsuki Saito
Takashi Irie
Kei Sato
ResearchOpen Access25 Nov 2021
Nature

Volume: 602, P: 300-306
Soluble Polyimides Based on 2,3,5-Tricarboxycyclopentyl Acetic Dianhydride

Yusuke Tsuda
Yukio Tanaka
Nobuo Bessho
Research01 Jul 1997
Polymer Journal

Volume: 29, P: 574-579
Soluble Copolyimides Based on 2,3,5-Tricarboxycyclopentyl Acetic Dianhydride and Conventional Aromatic Tetracarboxylic Dianhydrides

Yusuke Tsuda
Kenichi Etou
Nobuo Bessho
Research01 Mar 1998
Polymer Journal

Volume: 30, P: 222-228
Synthesis and Gas Permeability of Aromatic Polyamide and Polyimide Having Oligodimethylsiloxane in Main-Chain or in Side-Chain

Yusuke Kawakami
Shan-Pu Yu
Toshihiro Abe
Research01 Oct 1992
Polymer Journal

Volume: 24, P: 1129-1135
Synthesis and Characterization of New Side-Chain Liquid Crystalline Polyoxazolines

Kyung-Min Kim
Yusuke Imai
Yoshiki Chujo
Research01 Aug 2000
Polymer Journal

Volume: 32, P: 657-664
Non-human primate seasonal transcriptome atlas reveals seasonal changes in physiology and diseases

Metabolic, immune and endocrine systems undergo seasonal changes in animals. Here the authors report the seasonal transcriptome of 80 tissues collected over 1 year from male and female rhesus macaques as well as sex differences in seasonally oscillating genes.

Junfeng Chen
Kousuke Okimura
Takashi Yoshimura
ResearchOpen Access28 Apr 2025
Nature Communications

Volume: 16, P: 1-17
Author Correction: Chemigenetic indicators based on synthetic chelators and green fluorescent protein

Wenchao Zhu
Shiori Takeuchi
Robert E. Campbell
Amendments and Corrections21 Apr 2023
Nature Chemical Biology

Volume: 19, P: 790
CAR T or NK cells targeting mismatched HLA-DR molecules in acute myeloid leukemia after allogeneic hematopoietic stem cell transplant

Ikeda et al. report that HLA-DRB1 can serve as a leukemia-specific target for CAR T or natural killer cell-based therapy in patients with AML after allogeneic hematopoietic stem cell transplantation.

Shunya Ikeda
Kana Hasegawa
Naoki Hosen
Research24 Mar 2025
Nature Cancer

Volume: 6, P: 595-611
Cullin-5 deficiency promotes chimeric antigen receptor T cell effector functions potentially via the modulation of JAK/STAT signaling pathway

Chimeric antigen receptor (CAR) T cell therapy is a promising cancer treatment, but further optimization is still direly needed. Here the authors perform a CRISPR screen in CAR T cells to find Cul5 as a negative regulator, with Cul5 deficiency and subsequently enhanced JAK/STAT signaling attributed to improved CAR T efficacy in mouse tumor models.

Yoshitaka Adachi
Seitaro Terakura
Hitoshi Kiyoi
ResearchOpen Access10 Dec 2024
Nature Communications

Volume: 15, P: 1-14
Identification and replication of sex-dimorphic protein quantitative trait loci across multiple ancestries and their associations with diseases

Youngjune Bhak
Vasilis Raptis
Albert Tenesa
ResearchOpen Access28 Aug 2025
Scientific Reports

Volume: 15, P: 1-16
Na⁺-V-ATPase inhibitor curbs VRE growth and unveils Na⁺ pathway structure

The authors identify V-161, a compound that inhibits enterococcal Na⁺-V-ATPase and reduces VRE colonization in mice. The high-resolution structure of V-161 reveals its action on the Na+ transport pathway, offering new therapeutic insights.

Kano Suzuki
Yoshiyuki Goto
Takeshi Murata
Research21 Nov 2024
Nature Structural & Molecular Biology

Volume: 32, P: 450-458
Soluble Polyimides Based on Long-chain Alkyl Groups via Amide Linkages

Yusuke Tsuda
Manami Kojima
Jae Min Oh
Research04 Mar 2008
Polymer Journal

Volume: 40, P: 354-366
Structure and Properties of the Mesophase of Syndiotactic Polystyrene IV. Release of Guest Molecules from δ Form of Syndiotactic Polystyrene by Time Resolved FT-IR and WAXD Measurement

Atsushi Saitoh
Devaraj Amutharani
Sigeru Okamoto
Research01 Nov 2003
Polymer Journal

Volume: 35, P: 868-871
Synthesis and Optical Activity of Polyamides Derived from Optically Active Spiro[3.3]heptane-2,6-dicarboxylic Acid

Hongzhi Tang
Masaki Baba
Yusuke Kawakami
Research01 Mar 1999
Polymer Journal

Volume: 31, P: 313-315
Achievement of guideline-recommended target blood pressure is associated with reducing the risk of hemorrhagic and ischemic stroke in Japanese coronary artery disease patients -the CLIDAS study-

Yusuke Oba
Tomoyuki Kabutoya
Ryozo Nagai
Research19 Sept 2024
Hypertension Research

Volume: 48, P: 632-639
Endoplasmic reticulum stress sensor protein PERK in hepatic stellate cells promotes the progression of hepatocellular carcinoma via p38δ MAPK/IL-1β axis

Makoto Morita
Yoshio Tokumoto
Yoichi Hiasa
ResearchOpen Access06 Jun 2025
Scientific Reports

Volume: 15, P: 1-14
Soluble Polyimides Based on Alkyloxydiaminobenzene

Yusuke Tsuda
Kenichi Kanegae
Satoshi Yasukouchi
Research01 Nov 2000
Polymer Journal

Volume: 32, P: 941-947
Soluble Polyimides Based on Alkyldiaminobenzophenone

Yusuke Tsuda
Takehiro Kawauchi
Shuntaro Mataka
Research01 Jul 2000
Polymer Journal

Volume: 32, P: 594-601
Mesoporous metallic rhodium nanoparticles

Mesoporous noble metal nanostructures offer great promise in catalytic applications. Here, Yamauchi and co-workers synthesize mesoporous rhodium nanoparticles using polymeric micelle templates, and report appreciable activities for methanol oxidation and NO remediation.

Bo Jiang
Cuiling Li
Yusuke Yamauchi
ResearchOpen Access19 May 2017
Nature Communications

Volume: 8, P: 1-8
Comparison of the incidences of anastomotic leakage when PDSII or LACLON are used in esophago-gastric conduit handsewn anastomosis after esophagectomy

Yusuke Sato
Satoru Motoyama
Yoshihiro Minamiya
ResearchOpen Access24 Sept 2020
Scientific Reports

Volume: 10, P: 1-8
Comparative study of MAFLD as a predictor of metabolic disease treatment for NAFLD

Jin Imai
Shinji Takashimizu
Yasuhiro Nishizaki
ResearchOpen Access11 Jun 2024
Scientific Reports

Volume: 14, P: 1-7
Association of variations in HLA class II and other loci with susceptibility to EGFR-mutated lung adenocarcinoma

EGFR mutations in lung adenocarcinoma are more frequent in East Asians compared to other populations. Here, the authors carry out a genome-wide association study in EGFRmutant cancers and identify loci that are associated with risk of developing this molecular subtype of cancer.

Kouya Shiraishi
Yukinori Okada
Takashi Kohno
ResearchOpen Access09 Aug 2016
Nature Communications

Volume: 7, P: 1-7
The SARS-CoV-2 Omicron BA.1 spike G446S mutation potentiates antiviral T-cell recognition

Mutations in the spike of SARS-CoV-2 can result in the escape of the neutralising antibody response but may retain susceptibility to the cellular immune response. Here the authors show the G446S mutation in the spike protein of Omicron BA.1 is associated with altered antigen presentation and potentiates activation of specific T cell immunity.

Chihiro Motozono
Mako Toyoda
Takamasa Ueno
ResearchOpen Access21 Sept 2022
Nature Communications

Volume: 13, P: 1-11
Chemigenetic indicators based on synthetic chelators and green fluorescent protein

Chemigenetic combination of a synthetic ion-recognition motif and a protein-based fluorophore resulted in the development of calcium and sodium ion sensors.

Wenchao Zhu
Shiori Takeuchi
Robert E. Campbell
Research22 Sept 2022
Nature Chemical Biology

Volume: 19, P: 38-44
Improvement of lateral property of unidirectional-strengthened CFRP laminates using recycled carbon fiber

Annisa Prita Melinda
Rino Yamamoto
Yukihiro Matsumoto
ResearchOpen Access22 Aug 2023
Scientific Reports

Volume: 13, P: 1-8
Structural insights into selective interaction between type IIa receptor protein tyrosine phosphatases and Liprin-α

Synaptic organizers are cell-adhesion molecules capable of inducing synaptic differentiation through transsynaptic interactions. Here the authors present the crystal structure of the intracellular interaction between the synaptic organizer PTPδ and Liprin-α to reveal the structural mechanism of intracellular molecular interactions for IIa-RPTP-mediated synapse formation.

Maiko Wakita
Atsushi Yamagata
Shuya Fukai
ResearchOpen Access31 Jan 2020
Nature Communications

Volume: 11, P: 1-10
PKR associates with 4.1R to promote anchorage-independent growth of hepatocellular carcinoma and lead to poor prognosis

Yusuke Okujima
Takao Watanabe
Yoichi Hiasa
ResearchOpen Access13 Nov 2024
Scientific Reports

Volume: 14, P: 1-14
A Lin28 homologue reprograms differentiated cells to stem cells in the moss Physcomitrella patens

Land plants and metazoans are both able to reprogram differentiated cells to stem cells under certain circumstances. Here the authors show that the moss CSP1 protein, which shares conserved domains with the mammalian pluripotent stem cell factor Lin28, promotes reprogramming of leaf cells to apical stem cells.

Chen Li
Yusuke Sako
Mitsuyasu Hasebe
ResearchOpen Access27 Jan 2017
Nature Communications

Volume: 8, P: 1-13
Epidemiology of respiratory viruses according to age group, 2023–24 winter season, Kyoto, Japan

Yasufumi Matsumura
Masaki Yamamoto
Miki Nagao
ResearchOpen Access06 Jan 2025
Scientific Reports

Volume: 15, P: 1-7
Lower local recurrence rate after robot-assisted thoracoscopic esophagectomy than conventional thoracoscopic surgery for esophageal cancer

Satoru Motoyama
Yusuke Sato
Yoshihiro Minamiya
ResearchOpen Access24 Mar 2021
Scientific Reports

Volume: 11, P: 1-8
Therapeutic effects of the PKR inhibitor C16 suppressing tumor proliferation and angiogenesis in hepatocellular carcinoma in vitro and in vivo

Takao Watanabe
Hiroko Ninomiya
Yoichi Hiasa
ResearchOpen Access20 Mar 2020
Scientific Reports

Volume: 10, P: 1-9
Structural basis of trans-synaptic interactions between PTPδ and SALMs for inducing synapse formation

Synaptic organizers are cell adhesion molecules that facilitate synapse formation through trans-synaptic interactions. Here the authors give molecular insights into synaptic differentiation by determining the structures of the synaptic adhesion-like molecules SALM2 and SALM5 bound to the presynaptic organizer PTPδ.

Sakurako Goto-Ito
Atsushi Yamagata
Shuya Fukai
ResearchOpen Access18 Jan 2018
Nature Communications

Volume: 9, P: 1-9
Novel method for rapid fluorescence in-situ hybridization of ALK rearrangement using non-contact alternating current electric field mixing

Satoshi Fujishima
Kazuhiro Imai
Yoshihiro Minamiya
ResearchOpen Access08 Nov 2017
Scientific Reports

Volume: 7, P: 1-7
A genome-wide association study identifies PLCL2 and AP3D1-DOT1L-SF3A2 as new susceptibility loci for myocardial infarction in Japanese

Megumi Hirokawa
Hiroyuki Morita
Michiaki Kubo
Research11 Jun 2014
European Journal of Human Genetics

Volume: 23, P: 374-380
Orbital-resolved visualization of single-molecule photocurrent channels

Atomic-level imaging of photocurrents in a single molecule is achieved by combining a tunable laser with scanning tunnelling microscopy, revealing how photons turn into electric current via a photoexcited molecule.

Miyabi Imai-Imada
Hiroshi Imada
Yousoo Kim
Research30 Mar 2022
Nature

Volume: 603, P: 829-834
A fungal sesquiterpene biosynthesis gene cluster critical for mutualist-pathogen transition in Colletotrichum tofieldiae

Plant-associated fungi range from pathogens to mutualists. Here the authors identify a gene cluster in a Colletotrichum tofieldiae strain that is required to allow the fungus to transition from a mutualist to a pathogen depending on the nutritional status of the host.

Kei Hiruma
Seishiro Aoki
Yusuke Saijo
ResearchOpen Access06 Sept 2023
Nature Communications

Volume: 14, P: 1-18
A Novel Catalyst System for Cationic Polymerization of Styrene Derivatives. Combination of Platinum(0) Complex and Methyldichlorosilane

Motoi Oishi
Yusuke Kawakami
Research01 Oct 2001
Polymer Journal

Volume: 33, P: 765-772
Temporal identity transition from Purkinje cell progenitors to GABAergic interneuron progenitors in the cerebellum

GABAergic neuron progenitors in the cerebellum give rise to Purkinje cells and GABAergic interneurons. Here the authors show that the transcription factors Olig2 and Gsx1 regulate an identity transition from Purkinje cell progenitors to interneuron progenitors during mouse development.

Yusuke Seto
Tomoya Nakatani
Mikio Hoshino
Research18 Feb 2014
Nature Communications

Volume: 5, P: 1-13
The Japanese Society of Hypertension Guidelines for the Management of Hypertension (JSH 2019)

Satoshi Umemura
Hisatomi Arima
Nobuhito Hirawa
Reviews02 Aug 2019
Hypertension Research

Volume: 42, P: 1235-1481
Salt and potassium intake evaluated with spot urine and brief questionnaires in combination with blood pressure control status in hypertensive outpatients in a real-world setting

Masanobu Yamazato
Atsushi Sakima
Yusuke Ohya
Research03 Aug 2021
Hypertension Research

Volume: 44, P: 1316-1325
Genetic variation in PSCA is associated with susceptibility to diffuse-type gastric cancer

Hiromi Sakamoto
Kimio Yoshimura
Setsuo Hirohashi
Research18 May 2008
Nature Genetics

Volume: 40, P: 730-740

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