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Therapies for treating bacterial infection and increasing wound healing are needed. Here the authors report a liposozyme that combines reactive oxygen species generation and scavenging for antibacterial action and modulation of redox and immune homeostasis, increasing wound healing.

Ten years after the discovery of the Higgs boson, the ATLAS  experiment at CERN probes its kinematic properties with a significantly larger dataset from 2015–2018 and provides further insights on its interaction with other known particles.

Turley and colleagues find that Gremlin1-expressing lymph node fibroblastic reticular cells support dendritic cell homeostasis via provision of FLT3L.

Hybrid organic-inorganic trihalide perovskites can make remarkable optoelectronic devices but their spin characteristics are less investigated. Here Wang et al. show spin-polarized carriers injection into methylammonium lead bromide films with long lifetime and realize spin LEDs and spin valves.

The development of practical photonic quantum technologies will be aided by the spatial control of entangled photons. Lenget al. achieve on-chip spatial control of entangled photons by using domain engineering, rather than by using external optical elements.

Understanding the relationship between coherent twin boundaries and fatigue cracking is challenging. Here, the authors engineer the orientation of a twin boundary in a copper bicrystal, finding that fatigue crack nucleation varies with boundary orientation relative to the load axis.

Analysis of a set of 1,863 bursts from the repeating source FRB 20201124A provides evidence of a complicated magnetized site within about an astronomical unit from the source in a barred galaxy.

Whole-genome sequencing data for 2,778 cancer samples from 2,658 unique donors across 38 cancer types is used to reconstruct the evolutionary history of cancer, revealing that driver mutations can precede diagnosis by several years to decades.

Multi-omics datasets pose major challenges to data interpretation and hypothesis generation owing to their high-dimensional molecular profiles. Here, the authors develop ActivePathways method, which uses data fusion techniques for integrative pathway analysis of multi-omics data and candidate gene discovery.

With the generation of large pan-cancer whole-exome and whole-genome sequencing projects, a question remains about how comparable these datasets are. Here, using The Cancer Genome Atlas samples analysed as part of the Pan-Cancer Analysis of Whole Genomes project, the authors explore the concordance of mutations called by whole exome sequencing and whole genome sequencing techniques.

The characterization of 4,645 whole-genome and 19,184 exome sequences, covering most types of cancer, identifies 81 single-base substitution, doublet-base substitution and small-insertion-and-deletion mutational signatures, providing a systematic overview of the mutational processes that contribute to cancer development.

Projective representations of crystal symmetries are indispensable for understanding artificial crystals. Here, authors establish a unified theory of projective crystal symmetries with time-reversal invariance, and construct models for all 458 projective symmetry algebras for the 17 two-dimensional wallpaper groups.

Brain-wide recordings in mice reveal that prior expectations are distributed through recurrent loops across all levels of cortical and subcortical processing.

The transcription factor CREM is a pivotal regulator of NK cell function, making CREM a valuable target to increase the efficacy of anticancer immunotherapies based on this cell population and chimeric antigen receptors.

Amorphous films with tunable thermal conductivity are needed for semiconductor/aerospace fields. Amorphous Al(Ti)N nanoparticles have negligible effect on thermal conductivity of Si₃N₄ 2 W m⁻¹K⁻¹, while incorporating crystal TiN phases increases to 15 W m⁻¹K⁻¹.

Some cancer patients first present with metastases where the location of the primary is unidentified; these are difficult to treat. In this study, using machine learning, the authors develop a method to determine the tissue of origin of a cancer based on whole sequencing data.

Genetically encoded voltage indicators (GEVIs) enable fast tracking of membrane voltage in live neurons. Here, the authors use soma-targeted ASAP4.4-Kv to visualize electrical activity in sensory ganglia, revealing synchronization and altered coding after injury.

The lactate metabolite N-lactoyl-phenylalanine (Lac-Phe) plays a role in suppressing food intake and body weight. Here, the authors identify kidney transporters responsible for the renal excretion of Lac-Phe. This discovery highlights a pathway for Lac-Phe regulation in mice and humans.

Wang et al. present E3-CryoFold, a deep learning method for cryo-EM structure determination that enables end-to-end training and one-shot inference This method reduces inference times while boosting template modelling scores against comparable methods.

A repeating fast radio burst co-located with a persistent radio source and associated with a dwarf host galaxy of a high star-formation rate has been detected.

In topological insulators, studies have largely concentrated on the spin part of the wavefunction. But the spin–orbit coupling is strong, so the orbital components of the wavefunction need to be measured as well. Surprisingly, the orbital wavefunction turns out to be asymmetric about the Dirac point.

The coexistence of topological and superconducting states in a single layer of FeSe on a SrTiO₃ substrate is reported.

The realization of high-performance flexible perovskite/crystalline-silicon tandem solar cells requires efficient photocarrier transport and mitigation of residual stress. Here, authors reveal the critical role of perovskite phase homogeneity, achieving flexible devices with efficiency of 29.88%.

Whole-genome sequencing data from more than 2,500 cancers of 38 tumour types reveal 16 signatures that can be used to classify somatic structural variants, highlighting the diversity of genomic rearrangements in cancer.

The CMS Collaboration reports the study of three simultaneous hard interactions between quarks and gluons in proton–proton collisions. This manifests through the concurrent production of three J/ψ mesons, which consist of a charm-quark–antiquark pair.

This study explores the magnitude, spatiotemporal variation and drivers of nitrous oxide emissions from Chinese livestock production over the past four decades. Scenario analysis is used to estimate emissions mitigation potential of different measures, their associated marginal abatement costs and the social benefits.

1T-TaS2 possesses complex electronic phase behaviors in transition-metal di-chalcogenides, undergoing several charge-ordered phases before finally into an insulating state of unknown origin. Here, the authors determine its electronic and structural properties experimentally, revealing its origin.

Cancers evolve as they progress under differing selective pressures. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, the authors present the method TrackSig the estimates evolutionary trajectories of somatic mutational processes from single bulk tumour data.

Giant THG anisotropy in 2D VOCl emerges from a synergistic coupling of charge-transfer Mott insulator behavior with intrinsic C₃ symmetry breaking.

Transition metal dichalcogenide nanotubes possess symmetry-breaking properties promising for fundamental physics research. Here, the authors report a direct synthesis of crystalline MoS₂ nanotubes exhibiting strong polarization and bulk photovoltaic effects.

Discovery of a biochemical mechanism through which lactate binds and inhibits the SUMO protease SENP1, stimulating timed degradation of cell cycle proteins, and resulting in mitotic exit.

A proper theoretical description for unconventional superconductivity in iron-based compounds remains elusive. Here, the authors, to capture the electron correlation strength and the role of Fermi surfaces, report ARPES measurements of three iron chalcogenide superconductors to establish universal features.

The synthesis of atom-thin amorphous films remains challenging as their thermodynamically favourable grains are neither two dimensional nor layered. Here a droplet-driven nanoribbon-to-film growth strategy is reported to achieve amorphous metal chalcogenides at the single-layer limit.

In this study, Weber et al., investigate the long-term survival and integration of human stem cell-derived neural progenitors into the stroke-injured mouse brains. They report grafted cells integrate into host circuits and mediate repair through graft-host crosstalk via neurexin, neuregulin, neural cell adhesion molecules, and SLIT signalling pathways.

A clinical study of women with abnormal breast mammograms establishes a workflow to evaluate the capability of breast photoacoustic computed tomography in the classification, monitoring and segmentation of lesions.

Symmetry plays a crucial role in defining the band topology. Here, the authors experimentally demonstrate that spacetime inversion symmetry can lead to Stiefel-Whitney topological charges and protect hinge states in an acoustic nodal-line semimetal.

The collective-flow-assisted nuclear shape-imaging method images the nuclear global shape by colliding them at ultrarelativistic speeds and analysing the collective response of outgoing debris.

Hyperbolic polaritons provide unprecedented control over light-matter interaction at extreme nanoscales. Here, the authors propose type-I hyperbolic metasurfaces supporting highly-squeezed magnetic designer polaritons with negative group velocity, which are magnetic analogs of hyperbolic polaritons in hexagonal boron nitride.

Magnetotransport signature of topological semimetal states has been observed but restricted at very low temperature. Here, Zhanget al. report magnetic field-modulated chiral charge pumping and valley diffusion in Cd₃As₂up to room temperature.

Heusler compounds have been predicted to host topological order with other emergent properties, which yet awaits for experimental evidence. Here, Liu et al. report a direct observation of topological surface states on half-Heusler compounds LnPtBi.

In somatic cells the mechanisms maintaining the chromosome ends are normally inactivated; however, cancer cells can re-activate these pathways to support continuous growth. Here, the authors characterize the telomeric landscapes across tumour types and identify genomic alterations associated with different telomere maintenance mechanisms.

Gas-evolving catalysts suffer from severe mass transport limitations under industrial conditions. Here, the authors report an interfacial metal-layer engineering strategy to separate bubble nucleation from active sites, enabling transfer-resistance-free electrocatalytic interfaces.

Jovian cusps are not well-known due to limited observations. Here, the authors show that the characteristics of charged particles in the Jovian cusps are similar to those of the Earth and Saturn cusps, and Jupiter’s polar cusp is located in the dusk-side sector, contradicting Earth-based predictions of a near-noon location.

Squeezed light field microscopy (SLIM) combines ideas from tomography and compressed sensing with light field microscopy to enable volumetric imaging at kilohertz rates, as demonstrated in blood flow imaging in zebrafish and voltage imaging in leeches and mice.

At the Relativistic Heavy Ion Collider, observations of two meson species produced by heavy-ion collisions, ϕ and K^*0, show surprising patterns of global spin alignment, being unexpectedly large and consistent with zero, respectively.

Current-induced motion of magnetic nanostructures, such as skyrmions or domain walls, is envisioned as a promising scalable technology for information storage. Yuet al.demonstrate near-room-temperature motion of skyrmions with current densities orders of magnitude lower than previously reported in domain walls.

Quantum electrodynamics predicts a rare process in which light is scattered by light. The ATLAS Collaboration reports signs of this elusive effect in the collisions of ultra-relativistic lead ions.