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The relation between magnetooptical activity and chirality has previously been confused. Chiral polymer films are presented with state-of-the-art Verdet constants, revealing the role of chirality, and a strategy to enhance the magnetooptical B term.

This study links the genomic basis of behavioral variation to specific cell populations in the brain. Here, authors find evidence for involvement of neural stem cells in the evolution and expression of bower-building behavior in cichlid fishes.

A spatial and single-cell transcriptomics study across multiple mammalian species identifies epidermal BMP signalling as a functional requirement for rete ridge formation, providing insight into mechanisms underlying hair density loss and wound healing.

Sivanandan, Leitmann, and colleagues present the CellPaint-POSH platform, which combines pooled CRISPR screening with Cell Painting. Using self-supervised deep learning on cell images, the method enables discovery of gene function and biological networks.

Cells rely on diversification and redundancy of protein chaperones to maintain proteostasis. Here, the authors show that two C. elegans orthologs of a chaperone have distinct roles in stress resistance, aging, and autophagy through an ER-phagy receptor-dependent pathway.

An ‘intracrine’ signaling mechanism is proposed whereby a G-protein-coupled receptor (free fatty acid receptor 4) senses locally released fatty acids on intracellular membranes associated with lipid droplets to efficiently regulate lipolysis in adipocytes.

Synthetic materials that can repeatedly self-repair, akin to biological systems, are vital to meeting the 21st century’s infrastructural demands. Here, authors develop fiber-reinforced composites with rapid and prolonged in situ self-healing while also preserving structural integrity.

Jeppesen, Sanchez et al. identify blebbisomes as large membrane-enclosed vesicles containing organelles and secreted by cells. Blebbisomes can both secrete and internalize exosomes and microvesicles.

The growth of wide-bandgap perovskites remains insufficiently controlled under hybrid deposition. Here, the authors introduce n-propylamine hydrochloride for regulating the oriented crystal growth, achieving maximum efficiency of 26.46% for two-terminal perovskite/organic tandem solar cells.

Perovskite solar cells can complement silicon photovoltaics in multijunction devices. Here, the authors optimize light harvesting in monolithic perovskite-on-silicon devices and fabricate a certified 23.6% efficient, 1 cm² tandem solar cell with a perovskite device that withstands damp heat tests.

Stability issues hinder the commercialization of perovskite solar cells. An evaporated, highly oriented wide-bandgap perovskite film is reported, enabled through an intermediate phase evolution, resulting in enhanced stability and efficiency.

Application of synthetic glycan (SG) preparations in gnotobiotic mice colonized with a defined bacterial community composed of members of the human gut microbiota identified a SG preparation that selectively altered the fitness of multiple bacteria.

Lee et al. show that DMXL1, a regulator of V-ATPase assembly, is recruited to lysosomes upon TRPML1 activation in a manner dependent on conjugation of ATG8 proteins on lysosomal membranes (CASM) and promotes lysosomal function.

Iron sulfide nanoclusters enable on-demand and local generation of nitric oxide, an important lipophilic messenger in the brain, allowing the modulation and investigation of nitric oxide-triggered neural signalling events.

The face reveals more than just emotion. Cazettes, Reato and colleagues show that subtle facial movements reveal hidden cognitive states, reflecting the brain’s ongoing computations and offering a noninvasive window into unexpressed thoughts and decisions.

Self-organized criticality can occur in cellular systems, but its origins remain unclear. Now it is shown that cytoskeletal criticality is influenced by the F-actin architecture and myosin active stress.

Here, Koster et al., model human papillomavirus and Chlamydia coinfection dynamics in patient-derived ectocervical organoids, and characterize the effects of multiple infections in the cellular microenvironment, potentially contributing to neoplasia.

Coenzyme Q (CoQ) is a lipid made in the inner mitochondrial membrane with antioxidant roles throughout the cell, but regulation of its cellular distribution is unclear. Here the authors identify two proteins that have reciprocal CoQ trafficking functions to help coordinate CoQ localization in yeast.

High-precision measurements suggest that the Earth and Moon have distinct oxygen isotope compositions. This implies distinct oxygen isotopic compositions of the proto-Earth and its impactor that were not fully homogenized by the Moon-forming impact.

Coarctate reactions, involving the simultaneous formation and cleavage of two bonds at single or multiple atoms, have remained largely unexplored for biomolecular applications. Here, the authors use an azo-ene-yne coarctate reaction to synthesize isoindazole-based N-heterocycles and explore their applications in the synthesis of unnatural amino acids and drug conjugates, and late-stage peptide functionalization.

This study reports the preparation of degradable poly(β-amino ester) microparticles as a promising replacement for nondegradable microplastics in cleansing products and food fortification, demonstrating effective cleansing, toxic element removal and robust nutrient protection with efficient release.

Detecting dilute airborne biomarkers is important in healthcare but is limited by the low sensitivity of current gas sensors. A portable, low-cost device is introduced that uses water condensation to enrich airborne biomarkers into a concentrated liquid, enabling existing liquid sensors to detect biomarkers with high sensitivity and broad accessibility.

The authors find that TDP-43 loss of function—the pathology defining the neurodegenerative conditions ALS and FTD—induces novel mRNA polyadenylation events, which have different effects, including an increase in RNA stability, leading to higher protein levels.

New analytical tools are needed to identify chemical degradation and failure mechanisms in Li-ion batteries. Here, the authors report an operando Raman spectroscopy method, based on hollow-core optical fibres, that enables monitoring the chemistry of liquid electrolytes during battery cycling.

The synthesis of aziridines—three-membered nitrogen-containing heterocycles—is achieved by a new method involving the electrochemical coupling of alkenes and amines, via a dicationic intermediate.

The authors describe a mechanism for the clearance of macromolecules from cerebrospinal fluid in which macromolecules traverse from periarterial to perivenous spaces, at sites where intersecting leptomeningeal perivascular (arteriovenous) spaces overlap.

The stability of perovskite tandem solar cells is an issue. Li et al. show that diamines improve the compositional homogeneity of a low-bandgap perovskite surface and form a low-dimensional barrier that passivates defects, leading to an operational stability of over 1,000 h.

α-Fluoromethyl arenes are common substructures in pharmaceuticals and agrochemicals but synthetic routes are still rare. Here the authors describe Pd-catalyzed Suzuki-Miyaura cross-coupling of α-fluorinated benzylic triflones with arylboronic acids affording structurally diverse α-fluorinated diarylmethanes.

Hundreds of RNAs and proteins are imaged in fixed tissue at subcellular resolution.

Mouse models expressing liver apoE in the absence of brain apoE reveal detrimental effects of peripheral apoE4 associated with Alzheimer’s risk on cognition and amyloid pathology through compromising vascular integrity and function.

Synthetic Notch (SynNotch) receptors can be used to endow cells with custom sense-and-respond capabilities. Here, the authors introduce a fluorescein-binding SynNotch as a versatile tool for controlling gene expression responses to diverse stimuli via ligands based on fluorescein-conjugates.

The authors show that polyglutamylation of spindle microtubules is essential for error-free chromosome segregation and is mediated through Tubulin Tyrosine Ligase Like 11 (TTLL11), which is found to be frequently downregulated in cancer.

Here they identify the C. elegans homolog of Sjogren’s Syndrome Nuclear Antigen 1 as a centriole-stabilizing factor. In the absence of SSNA-1 centrioles assemble normally but are prone to fragmenting in the early embryo leading to multipolar spindle formation and embryonic lethality.

Deep-sea hydrothermal plumes support an array of microbial metabolisms, but the fate of organic carbon in these systems is unknown. Here, the authors used metabolic rate assays and metagenomic data to show that heterotrophic bacteria contribute significantly to carbon cycling in the deep sea.

Materials typically break down in response to the repeated mechanical forces that they experience during use. Now, it has been shown that a mechanochemically active polymer can respond to shear forces by forming more bonds than are broken, leading to improved mechanical properties under conditions that would otherwise be destructive.

One-dimensional linear carbon chains reaching a length close to 800 nm have been synthesized at high temperature and high vacuum using double-walled carbon nanotubes as nanoreactors.

Genome-scale DNA methylation maps over early human embryogenesis and embryonic stem cell derivation provide insights into shared and unique modes of regulation when compared to the mouse model, including relationships to gene expression, transposable element activity, and maternal-specific methylation.

De novo designed interleukin-4 mimetics were engineered that induce biased signaling activation and exhibit high thermal stability. These mimetics offer insight into cytokine signaling and can be directly incorporated into 3D-printed biomaterials

This multi-omic longitudinal analysis of the healthy human peripheral immune system constructs the Human Immune Health Atlas and assembles data on immune cell composition and state changes with age, including responses to cytomegalovirus infection and influenza vaccination.

The effect of defects on MXene structural transitions in high-temperature environments is shown. Further, defect occupied alkali cations are shown to improve MXenes’ phase stability and control surface diffusion related phase changes.

Ventral striatal dopamine D3 and D1 receptors regulate motivation and reinforcement, respectively, through dissociable physiological actions.

Physiological matching of blood flow to the demand for oxygen by the heart is required for sustained cardiac health, yet the underlying mechanisms are obscure. Here, the authors report a key role for acute modifications to the redox state of intracellular pyridine nucleotides in coronary smooth muscle and their impact on voltage-gated K + channels in metabolic vasodilation

Sandhoff disease (SD) is a lysosomal storage disorder caused by deficiency in the β subunit of the β-hexosaminidase enzyme. Here, the authors show via bone marrow-based microglial replacement in a SD mouse model that myeloid-derived β-hexosaminidase is necessary for maintaining neuronal health.

Feedback from the oral cavity to thirst-promoting neurons in the subfornical organ (SFO) during eating and drinking is integrated with information about blood composition, providing a prediction of how oral consumption will affect fluid balance and leading to changes in behaviour.

The authors present a characterization of complex X-linked lncRNA loci with sex- and allele-specific epigenetic signatures that serve as a platform for the largest chromatin structures in mammals, thereby elucidating diverse phenotypes and combinatorial effects on autosomes.

Structured illumination microscopy is usually limited to 2 times spatial resolution improvement over the diffraction limit. Here, the authors introduce a metamaterial structure to generate speckle-like sub-diffraction limit illumination patterns in the near field, and achieve a 7-fold resolution improvement down to 40 nm.

Although the trivalent actinides are similar to the lanthanide series in terms of chemistry and bonding, their structures and properties can diverge significantly. Here, the authors report a series of complexes of the trivalent actinides Np(III) through Cf(III) along with their lanthanide counterparts using a polarizable non-innocent, sulfur-donor ligand.

Knee osteoarthritis has a sex-specific phenotype with post-menopausal persons experiencing the highest incidence. Here the authors investigate the underlying mechanisms in a mouse model of menopause and find that the loss of 17β-estradiol and progesterone enhanced susceptibility to senescence, extracellular matrix disassembly and cartilage degradation.