Search

Zinc is an essential micronutrient for plants, however its excess causes cellular damage. Here, the authors report that natural variation of Trichome Birefringence (TBR) gene confers zinc toxicity tolerance through modulating root cell wall pectin methylesterification in Arabidopsis.

Nitrogen deposition can increase plant biomass and reduce plant diversity, but herbivores are predicted to offset these effects by increasing consumption. Here, the authors demonstrate that added nitrogen can disrupt top-down control by herbivores, reducing herbivore abundance and increasing plant biomass and community dominance.

A resource of human RNA-protein associations is produced using a sequencing-based method.

Achieving room-temperature blackbody-sensitive photodetectors with an ultrabroadband response is challenging. Here, the authors report a bioinspired detector using the 2D flat-band quantum material Nb3I8 that enables sensitive detection from the shortwave to the very long-wave infrared.

This study identifies brain connectivity patterns linked to the duration of methamphetamine abstinence in individuals with methamphetamine use disorder. The identified networks were validated in an out-of-sample replication.

CryoDRGN-AI is a deep learning system for ab initio reconstruction of dynamic biomolecular complexes from cryo-electron microscopy and cryo-electron tomography imaging datasets.

Optical tweezers based on focused laser beams are widely used for biophysical measurements of single molecules in vitro. Here Zhong et al. use infrared optical tweezers to trap and manipulate red blood cells within subdermal capillaries in living mice.

Zhong et al. report a CuInP₂S₆ photodetector array that leverages microscopic ion–electron interactions to achieve tuneable photoresponse with light wavelength and intensity. These capabilities enable in-sensor image processing and offer potential assistance for addressing visual deficiencies, such as color blindness.

Adrenergic and muscarinic receptors are key GPCRs involved in vital functions. Here, the authors engineer toxin variants that selectively target α2A and M4AChR, offering new tools and therapeutic leads through a structure-guided design strategy.

This study maps chromatin accessibility at single-cell resolution in rice and related grasses, revealing how regulatory DNA elements evolve across cell types and species and identifying potential silencers that control gene expression.

Long-range interactions are challenging for machine learning interatomic potentials (MLIPs). Here, authors show that, by just learning from energies and forces, MLIPs can accurately capture electrostatics and predict atomic charges.

‘Ultrathin’ gold interlayers are shown to form nanoparticles that balance optical losses and electrical contact, enabling efficient perovskite–perovskite integration for scalable and durable triple-junction photovoltaics.

Lipid nanoparticles are the gold standard for mRNA delivery but suffer from low loading capacity. Here, the authors report on the use of manganese ions to form mRNA rich cores within lipid nanoparticles which increased mRNA loading, reducing the lipid needed and increasing transfection and immune response in vivo.

Tandem electro-biocatalytic systems present a versatile platform for producing a variety of synthetic products using CO₂ as a starting material. Here direct ocean carbon capture is incorporated into an electrolysis scheme to produce formic acid from CO₂ dissolved in seawater that is subsequently converted to succinate in a bioreactor.

Dihydrouridine (D) is an abundant RNA modification but its functions are currently unclear. Here, authors develop CRACI, a sensitive method for transcriptome-wide, single-base D mapping, identifying sites across mammalian and plant transcriptomes and identifying DUS2L as a mitochondrial D writer.

Converting plastic waste into single-atom catalysts (SACs) provides both a sustainable approach to waste management and a source of valuable catalytic materials. Here, the authors present a straightforward, scalable method to upcycle plastic waste into diverse porous SACs and showcase their outstanding performance across multiple catalytic reactions.

Single-atom catalysts (SACs) face synthesis and structural control challenges. Here a scalable NaCl-template strategy is developed to produce diverse SACs with tailored coordination, enhancing catalytic performance for environmental and energy uses.

Noise-induced synchronization is known in classical systems and has recently been proposed in quantum many-body settings. Here, the authors experimentally demonstrate stable and entangled synchronized oscillations at the ends of a superconducting qubit chain by applying Gaussian noise to a single qubit.

The sedimentary DNA signal obtained from Black Sea sedimentary archives revealed the past dynamics of microorganisms able to transform mercury into the neurotoxin methylmercury. Water column anoxia during the mid-Holocene Climate Optimum appeared to be the main driver of potential methylmercury production in the Black Sea.

Granulosa cells are the key lineage driving continuous folliculogenesis. Here, the authors reveal that the transcription factor Fosl2 reconfigures chromatin state in these cells and coordinates vital signalling pathways for ovulation and reproduction.

Rudensky and colleagues demonstrate a context-dependent differential requirement for Foxp3 for T_reg cell transcriptional and functional programs.

Using extended-gate capacitive coupling and diode connection, stretchable biosensors with a built-in differential circuit design can be created that can offer low signal distortion under bias stress instability, uniaxial strain, compression and temperature variations.

H₂O₂ photosynthesis offers a green alternative to traditional methods, but challenges remain in charge separation and reaction selectivity. Here, the authors report Z-scheme photocatalysts where sulfur vacancy regulates O₂ adsorption configuration, enhancing H₂O₂ production with high selectivity.

The persistence of myofibroblasts after wound healing is ultimately responsible for scarring. Here, the authors show that fibromodulin enhances interleukin 1β ternary complex formation, promoting myofibroblast apoptosis and providing a potential strategy to mitigate scarring.

The Antarctic Circumpolar Current (ACC) since the Last Interglacial is reconstructed, showing orbital-scale shifts in ACC position driven by eccentricity and precession, possibly counteracting the predicted southward shift due to global warming.

This study presents 3D-SpecDIM, a method capable of concurrently capturing both rapid 3D positional dynamics and physicochemical parameter changing dynamics of the biomolecules, enabling high-speed 3D tracking and spectral analysis in live cells.

Quantum errors present a fundamental challenge for quantum information storage and manipulation. Zhong et al.implement a protocol based on quantum measurement uncollapsing to detect and reject quantum errors in a superconducting qubit, thereby increasing the storage time of a quantum state by a factor of three.

Manganese is essential but toxic in excess. Here, the authors report cryo-EM structures of the Mn²⁺ transporter SLC30A10, define its Mn²⁺-binding site, and show how a disease-linked mutation impairs transport, mitochondria and cell viability, advancing understanding of Mn²⁺ homeostasis.

Sweat sensors are important in personalized healthcare using natural oxidase to target biomolecules but these reactions are susceptible to external interference. Here, the authors report tryptophan- and histidine-treated copper metal-organic frameworks which show highly selective activity for ascorbate oxidation and can serve as an efficient ascorbate oxidase-mimicking material in sensitive sweat sensors.

Using flexible electronics and setae modules, the authors develop small and adaptable soft robots which sense the surrounding environment, make decisions using onboard AI, and perform complex movements, overcoming previous limitations in autonomy and terrain adaptability.

3d-atom intercalated transition metal dichalcogenides present complex behaviour due to the interplay between localized and itinerant electrons. Here, the authors investigate Cr_1/3NbS₂ and Mn_1/3NbS₂, revealing that Hund’s coupling and orbital hybridization significantly alter electronic structures, inducing strong spin polarization and anomalous changes in the density of states at the Fermi level.

Single-atom catalysts, particularly metal/nitrogen-doped carbons, have become a versatile platform for fine-tuning electronic interactions with reactants and controlling thermodynamic selectivity. Here, the authors show that the catalytic ozonation activity of single-atomic Co–N₄ sites can be electronically modulated by adjusting the density of Co nanoparticles on the carbon matrix.

Here the authors show that crotonate and H3K14cr levels are increased in regenerating crypts. Treatment with sodium crotonate (NaCr) significantly alleviates dextran sulfate sodium induced colitis, an effect largely dependent on HBO1-mediated H3K14cr.

The partial hydrogenation of multi-substituted allenes is a highly useful reaction but impeded by difficult selectivity control. Now, pincer cobalt catalysts enable this transformation through metal–ligand cooperative interactions, achieving ligand-controlled selective allene semihydrogenation in a divergent manner.

An untethered jamming mechanism uses magnetic fields to control interactions between soft-ferromagnetic composites with designed magnetization profiles. Stiffness, damping, and shapelocking are tuned for programmable robotic materials.

The relationship between interacting sites and catalytic mechanisms in single-atom catalysts remains unclear. Here a support engineering strategy is used to tune the binding strength between single-metal atoms and the support, optimizing active Cu sites and enhancing CH₄ formation.

Basalt clasts returned by Chang’e-6 suggest a lunar farside mantle potential temperature that is approximately 100 °C cooler than the nearside mantle, according to a petrologic study combined with thermobarometric modelling and remote sensing data.

A fundamental objective of genomics is to track variations in gene expression program. Here, authors developed Dyan-vivo-seq, which offers unprecedented insights into temporal RNA dynamics within intricate and dynamic biological systems at single-cell resolution.