Search

Tumor-associated macrophages play central roles in the cellular immune response in the tumor microenvironment. Here the authors implicate the m6A methyltransferase METTL3 in glioma progression by regulation of the ISG15/FASN modulated lipid metabolism in macrophage.

Achieving room-temperature blackbody-sensitive photodetectors with an ultrabroadband response is challenging. Here, the authors report a bioinspired detector using the 2D flat-band quantum material Nb3I8 that enables sensitive detection from the shortwave to the very long-wave infrared.

Achieving both high activity and selectivity in CH₄ photooxidation to C₂₊ hydrocarbons is challenging. This work shows that integrating photochemical and photothermal effects enhances both, enabling efficient CH₄ oxidative coupling to C₂₊ alkanes.

A pan-cancer analysis reveals TREM1⁺ PMN-MDSCs as key mediators of immunosuppression by remodeling the tumor microenvironment, highlighting TREM1 as a therapeutic target.

Xin-zhuan Su and colleagues report genome-wide SNP genotyping of 189 culture-adapted Plasmodium falciparum parasites and examine population structure, selection and recombination hotspots. They also conduct genome-wide association studies for resistance to seven different antimalarial drugs.

Cancer cells exploit altered metabolic pathways to dynamically regulate epigenetic methylations. Here, the authors show the canonical metabolic and nonmetabolic functions of PRPS2 in enhancing ATP utilization and SAM biosynthesis, promoting RNA m⁶A methylation for lung tumorigenesis and metastasis.

The inflammasome is an essential component of inflammatory processes and the host response to infection. Here the authors show that inflammasome activation modulates MyD88-IRF7 type I IFN signalling and anti-malaria immunity.

This study identifies a positive-feedback loop between the ACC and the VTA that mediates the mutual exacerbation between hyperalgesia and comorbid anxiodepressive-like behaviors and, thereby, the chronicity of neuropathic pain.

Cryo-EM structures and quantum calculation reveal LHCII as a controlling switch for the transition between light capture and excess energy dissipation, in response to lateral pressure and acid-induced conformational changes.

The prefrontal cortex is involved in cocaine abuse disorders. Here, the authors show that cocaine suppresses frontal association cortex (FrA) in awake mice and induces locomotor sensitization through a dopamine dependent VTA-vmPFC-FrA pathway.

Here, the authors show that two mutations in the Plasmodium de-ubiquitinase UBP1 alter the ubiquitination level, membrane localization, and ligand transport direction of multidrug resistance transporter 1 (MDR1), leading to multiple drug resistances.

Researchers demonstrate that cholesterol-enriched exosomes can deliver siRNA directly into cancer cells, bypassing normal cellular barriers and significantly enhancing gene silencing. This offers a more effective method for gene therapy applications.

Ferroelectrics, which exhibit excellent charge separation ability, suffer from poor photocatalytic activity. The authors unveil the limitations in charge extraction and offer strategies to design high-performance photocatalysts by eliminating surface defects.

Nicotine exposure from cigarette smoke modulates dopamine release in the brain, which is implicated in nicotine addiction, but how it does this is unclear. Here, in mouse brain slices, the authors show that nicotine inhibits cholinergic- but not dopaminergic-dependent dopamine release.

Non-syndromic cleft lip with palate is a common birth defect of unknown aetiology. Here, the authors discover 14 new genes associated with this condition, and show genetic heterogeneity in this and other non-syndromic orofacial clefting disorders.

While advanced oxidation processes show promise in wastewater treatment, the fate of pollutants and intermediates is yet to be understood. The organic carbon transfer process operates in many oxidation systems, and the accumulation of reaction by-products in catalyst’s surface weakens the catalytic performance.

Lymph node (LN) metastases after primary treatment may end up with disease recurrence and poor survival rate. Here this group designs a phospholipase A₂ (sPLA₂)-responsive nanosystem delivering doxorubicin for in vivo inhibition of both primary colorectal tumor progression and LN metastasis.

Immune checkpoint inhibition is a successful form of immune therapy; however response rates vary widely among individual patients. Here authors show that circulating small extracellular vesicles might contribute to poor response to anti-PD-1 treatment by carrying PD-1 and CD80 which results in higher level of vesicular PD-L1 expression in the circulation at the expense of expression on tumour cell membranes, causing immunosuppression.

Expansion of synovial fibroblast is associated with rheumatoid arthritis (RA) progression, but how this expansion is regulated is still not clear. Here the authors use a mouse RA model, single cell RNA sequencing and in vitro analyses to show that inducing ferroptosis and suppressing TNF signaling reduce fibroblast numbers and ameliorate experimental arthritis.

Photosynthesis in biological systems occurs in a noisy environment that reduces the lifetime of coherences in the excitation energy transfer. Here the author demonstrate that long-lasting coherences are protected by quantum phase synchronization, realized in dimers by exciton-vibrational coupling where energy dissipation occurs predominantly in resonant anti-symmetric collective modes.

While ferroelectric materials are promising candidates for solar water splitting, most examples show poor activities. Here, authors prepare charge-collecting nanostructures on the positive and negative domains of BaTiO₃ and demonstrate photocatalytic overall water splitting.

It remains unclear how nerve terminals sustain neurotransmitter release during intense activity. Yang et al. show that, in the calyx of Held, the retention of K⁺ channels in intermediate gating states between high-frequency spikes controls synaptic vesicle release by constraining presynaptic Ca²⁺influx.

Photocatalytic oxidation of methane through oxidative coupling presents a route to higher hydrocarbons but has suffered from low activity and uncontrolled product selectivity. Now, Au nanoparticles loaded onto a ZnO/TiO₂ heterostructure are shown to deliver high rate production of ethane.

Angiotensin II type 1 receptor (AT1R)-mediated acute catecholamine release is modulated by β-arrestin. Here the authors show that β-arrestin-1 recruits the Ca²⁺channel TRPC3 and the PLCγ to the AT1R-β-arrestin complex, triggering G protein-independent calcium influx and catecholamine secretion.

P2X receptors are ion channels that are controlled by the level of extracellular ATP. Here, Zhao et al.describe the coordinated allosteric changes in two protein domains that couple extracellular ATP-binding to channel gating and show that these changes are essential for the function of the proteins.

Color construction of black carbon fibers is a challenge due to their stable physicochemical properties. Here, the authors demonstrate the tunable structural color of carbon fibers endowed by the dynamic growth of carbon spheres using glucose.

Mosquito-derived xanthurenic acid (XA) is a trigger for gametogenesis of Plasmodium parasites. Here the authors show that the putative amino acid transporter GEP1 is required for XA-stimulated gametogenesis in Plasmodium yoelii and that it interacts with guanylyl cyclase α (GCα), a cGMP synthesizing enzyme in gametocytes.

Successful identification of mouse embryonic pre-haematopoietic stem cells at single-cell resolution.

Drug delivery in brain tumours is still a significant clinical concern. In this study, the authors develop a biomimetic lipoprotein nanoparticle for the efficient delivery of ATF5 siRNA inRas-activated brain cancer cells, where the nanoparticle is internalized by macropinocytosis in a Ras-dependent manner.

FHIRM-TPM is a miniature two-photon microscope capable of imaging fluorescently labeled neurons in the brains of freely behaving mice. It allows for imaging of spines or recording of neural activity with a frame rate up to 40 Hz.

The diperpenoid adenanthin covalently modifies the resolving cysteine from peroxiredoxins to inhibit the reduction of hydrogen peroxide, a second messenger in cells, and thereby activates pathways that promote the differentiation of leukemia cells.