Nature Search

ProPE expands the prime editing window and enhances gene editing efficiency where prime editing is inefficient

Prime editing is a CRISPR methodology whose efficiency declines with distance from the target sequence. Here the authors demonstrate prime editing with prolonged editing window, proPE, which extends the editing distance, enabling the use of prime editing for therapeutic interventions.

Sarah Laura Krausz
Dorottya Anna Simon
Ervin Welker
ResearchOpen Access10 Oct 2025
Nature Catalysis

P: 1-17
Neurodevelopmental outcome in infants with neonatal encephalopathy receiving hydrocortisone during therapeutic hypothermia: follow-up of the extended-CORTISoL trial

Kata Kovacs
Eniko Szakmar
Agnes Jermendy
ResearchOpen Access22 Sept 2025
Journal of Perinatology

P: 1-7
MAGI3–AKT3 fusion in breast cancer amended

Juan-Miguel Mosquera
Sonal Varma
Sandra J. Shin
Research15 Apr 2015
Nature

Volume: 520, P: E11-E12
Publisher Correction: An international perspective on the future of systemic sclerosis research

David J. Abraham
Carol M. Black
Thomas Krieg
Amendments and Corrections03 Mar 2025
Nature Reviews Rheumatology

Volume: 21, P: 249
Microglia contribute to neuronal synchrony despite endogenous ATP-related phenotypic transformation in acute mouse brain slices

Microglia undergo rapid phenotype changes in response to tissue disturbances but the impact of these changes on neuronal networks is unclear. Here, the authors show that microglia contribute to neuronal synchrony in acute brain slices, while their marked phenotypic transformation is influenced by injury-related focal ATP events.

Péter Berki
Csaba Cserép
Ádám Dénes
ResearchOpen Access26 Jun 2024
Nature Communications

Volume: 15, P: 1-24
histoCAT: analysis of cell phenotypes and interactions in multiplex image cytometry data

The histology topography cytometry analysis toolbox (histoCAT) enables quantitative analysis and exploration of highly multiplexed imaging data for better understanding of individual cells in the context of tissue architecture.

Denis Schapiro
Hartland W Jackson
Bernd Bodenmiller
Research07 Aug 2017
Nature Methods

Volume: 14, P: 873-876
Clinical and pathological features of lymphomas in the breast: a comprehensive multicentric study

Umberto Maccio
Anton Rets
Zsuzsanna Varga
ResearchOpen Access08 Aug 2025
Scientific Reports

Volume: 15, P: 1-11
Multielement Z-tag imaging by X-ray fluorescence microscopy for next-generation multiplex imaging

Multielement Z-tag X-ray fluorescence (MEZ-XRF) offers a new avenue for nondestructive and highly multiplexed tissue imaging and operates from the nanometer to whole-tissue scale, unlocking new biological observations.

Merrick Strotton
Tsuyoshi Hosogane
Bernd Bodenmiller
ResearchOpen Access31 Aug 2023
Nature Methods

Volume: 20, P: 1310-1322
The single-cell pathology landscape of breast cancer

A single-cell, spatially resolved analysis of breast cancer demonstrates the heterogeneity of tumour and stroma tissue and provides a more-detailed method of patient classification than the current histology-based system.

Hartland W. Jackson
Jana R. Fischer
Bernd Bodenmiller
Research20 Jan 2020
Nature

Volume: 578, P: 615-620
Pleomorphic adenomas and mucoepidermoid carcinomas of the breast are underpinned by fusion genes

Fresia Pareja
Arnaud Da Cruz Paula
Jorge S. Reis-Filho
ResearchOpen Access05 Jun 2020
npj Breast Cancer

Volume: 6, P: 1-7
Assessment of HMGA2 and PLAG1 rearrangements in breast adenomyoepitheliomas

Fresia Pareja
Felipe C. Geyer
Jorge S. Reis-Filho
ResearchOpen Access18 Jan 2019
npj Breast Cancer

Volume: 5, P: 1-5
Single-neuron representation of learned complex sounds in the auditory cortex

Using a combination of two-photon imaging and single-cell electrophysiology, the authors discover that associative learning induces the emergence of a unique subset of neurons in the auditory cortex, exhibiting high-rate bursting responses to the learned complex sounds but not to any of the constituents.

Meng Wang
Xiang Liao
Xiaowei Chen
ResearchOpen Access31 Aug 2020
Nature Communications

Volume: 11, P: 1-14
Highly multiplexed imaging of tumor tissues with subcellular resolution by mass cytometry

This paper reports the use of mass cytometry on adherent cells and tissue samples for highly multiplexed imaging at subcellular resolution.

Charlotte Giesen
Hao A O Wang
Bernd Bodenmiller
Research02 Mar 2014
Nature Methods

Volume: 11, P: 417-422
Recurrent hotspot mutations in HRAS Q61 and PI3K-AKT pathway genes as drivers of breast adenomyoepitheliomas

Adenomyoepithelioma is a rare tumor of the breast with an unknown genetic basis. Here the authors perform a genomic analysis of adenomyoepitheliomas revealing that their repertoire of somatic mutations vary according to the estrogen receptor (ER) status, and that ER-negative tumors harbor recurrent mutations in HRAS and PI3K pathway genes.

Felipe C. Geyer
Anqi Li
Jorge S. Reis-Filho
ResearchOpen Access08 May 2018
Nature Communications

Volume: 9, P: 1-16
From treatment to prevention: The evolution of digital healthcare

Sophie Park MPH.
Javier Garcia-Palacios PhD.
Zsuzsanna Varga PhD
Special Features25 Sept 2019
Nature Research Custom
An international perspective on the future of systemic sclerosis research

The diagnosis, treatment and management of systemic sclerosis (SSc) remains challenging, owing to the complexity of this disease. In this Perspective, an international group of experts discuss the future of SSc research and how the advent of innovative technologies will advance research into and understanding of SSc.

David J. Abraham
Carol M. Black
Thomas Krieg
Reviews14 Feb 2025
Nature Reviews Rheumatology

Volume: 21, P: 174-187
Identification of putative baroreceptors in human aortic arch by histological and omics analyses

Yankey Yundung
Jaroslav Pelisek
Benedikt Reutersberg
ResearchOpen Access07 May 2025
Hypertension Research

Volume: 48, P: 2083-2094
LOTOS-based two-photon calcium imaging of dendritic spines in vivo

Xiaowei Chen
Ulrich Leischner
Arthur Konnerth
Protocols13 Sept 2012
Nature Protocols

Volume: 7, P: 1818-1829
Biomarker dynamics and prognosis in breast cancer after neoadjuvant chemotherapy

Cristina Zarotti
Bärbel Papassotiropoulos
Zsuzsanna Varga
ResearchOpen Access07 Jan 2022
Scientific Reports

Volume: 12, P: 1-14
Results of a worldwide survey on the currently used histopathological diagnostic criteria for invasive lobular breast cancer

Maxim De Schepper
Anne Vincent-Salomon
Christine Desmedt
ResearchOpen Access03 Aug 2022
Modern Pathology

Volume: 35, P: 1812-1820
Association between cardiovascular care and neurodevelopmental outcomes in infants with neonatal encephalopathy and hemodynamic instability

Kata Kovacs
Regan E. Giesinger
Patrick J. McNamara
Research17 Feb 2025
Journal of Perinatology

Volume: 45, P: 1073-1080
Repeated diagnostic ultrasound exposure modifies the structural properties of CA1 dendrites and alters the hippocampal transcriptome

Zsuzsanna Winkler-Ferenczi
Bence Pelyvas
Tamas Papp
ResearchOpen Access22 May 2024
Scientific Reports

Volume: 14, P: 1-12
Ki-67 assessment in early breast cancer: SAKK28/12 validation study on the IBCSG VIII and IBCSG IX cohort

Zsuzsanna Varga
Qiyu Li
Thomas Ruhstaller
ResearchOpen Access19 Sept 2019
Scientific Reports

Volume: 9, P: 1-11
Cessation of CCL2 inhibition accelerates breast cancer metastasis by promoting angiogenesis

In mouse models of breast cancer, anti-CCL2 therapy—thought to be potentially useful in treating cancer—is shown to accelerate the growth of lung metastases on discontinuation due to a surge of recruitment of bone marrow monocytes and increased interleukin-6-dependent vascularization of the lung metastatic environment.

Laura Bonapace
Marie-May Coissieux
Mohamed Bentires-Alj
Research22 Oct 2014
Nature

Volume: 515, P: 130-133
The Hippo kinases LATS1 and 2 control human breast cell fate via crosstalk with ERα

Ablation of the large tumour suppressor kinases 1 and 2 promotes a luminal breast cell phenotype through stabilization of oestrogen receptor-α, thereby changing human breast cell fate.

Adrian Britschgi
Stephan Duss
Mohamed Bentires-Alj
Research09 Jan 2017
Nature

Volume: 541, P: 541-545
Plasma neutrophil extracellular trap level is modified by disease severity and inhaled corticosteroids in chronic inflammatory lung diseases

Zsófia Gál
András Gézsi
Csaba Szalai
ResearchOpen Access09 Mar 2020
Scientific Reports

Volume: 10, P: 1-9
Dual targeting of BCL-2 and MCL-1 in the presence of BAX breaks venetoclax resistance in human small cell lung cancer

Zsuzsanna Valko
Zsolt Megyesfalvi
Karin Schelch
Research14 Mar 2023
British Journal of Cancer

Volume: 128, P: 1850-1861
The role of the Aspergillus nidulans high mobility group B protein HmbA, the orthologue of Saccharomyces cerevisiae Nhp6p

Judit Ámon
Gabriella Varga
Zsuzsanna Hamari
ResearchOpen Access15 Oct 2022
Scientific Reports

Volume: 12, P: 1-15
Early prediction of acute necrotizing pancreatitis by artificial intelligence: a prospective cohort-analysis of 2387 cases

Szabolcs Kiss
József Pintér
Zsolt Szakács
ResearchOpen Access12 May 2022
Scientific Reports

Volume: 12, P: 1-11
Abnormal basement membrane results in increased keratinocyte-derived periostin expression in psoriasis similar to wound healing

Lili Borbála Flink
Ameneh Ghaffarinia
Renáta Bozó
ResearchOpen Access29 Sept 2023
Scientific Reports

Volume: 13, P: 1-10
Synthesis and biochemical evaluation of 17-N-beta-aminoalkyl-4,5α-epoxynormorphinans

Ferenc Ötvös
Edina Szűcs
Sándor Benyhe
ResearchOpen Access20 Nov 2023
Scientific Reports

Volume: 13, P: 1-16
A complete nicotinate degradation pathway in the microbial eukaryote Aspergillus nidulans

A novel nicotinate degradation pathway is described in Aspergillus nidulans, with metabolic products identified that were not previously found in prokaryotic species. This is the first such pathway to be described in a eukaryote.

Eszter Bokor
Judit Ámon
Zsuzsanna Hamari
ResearchOpen Access21 Jul 2022
Communications Biology

Volume: 5, P: 1-11
MATRIEX imaging: multiarea two-photon real-time in vivo explorer

Mengke Yang
Zhenqiao Zhou
Hongbo Jia
ResearchOpen Access28 Nov 2019
Light: Science & Applications

Volume: 8, P: 1-11

Search

ProPE expands the prime editing window and enhances gene editing efficiency where prime editing is inefficient

Neurodevelopmental outcome in infants with neonatal encephalopathy receiving hydrocortisone during therapeutic hypothermia: follow-up of the extended-CORTISoL trial

MAGI3–AKT3 fusion in breast cancer amended

Publisher Correction: An international perspective on the future of systemic sclerosis research

Microglia contribute to neuronal synchrony despite endogenous ATP-related phenotypic transformation in acute mouse brain slices

histoCAT: analysis of cell phenotypes and interactions in multiplex image cytometry data

Clinical and pathological features of lymphomas in the breast: a comprehensive multicentric study

Multielement Z-tag imaging by X-ray fluorescence microscopy for next-generation multiplex imaging

The single-cell pathology landscape of breast cancer

Pleomorphic adenomas and mucoepidermoid carcinomas of the breast are underpinned by fusion genes

Assessment of HMGA2 and PLAG1 rearrangements in breast adenomyoepitheliomas

Single-neuron representation of learned complex sounds in the auditory cortex

Highly multiplexed imaging of tumor tissues with subcellular resolution by mass cytometry

Recurrent hotspot mutations in HRAS Q61 and PI3K-AKT pathway genes as drivers of breast adenomyoepitheliomas

From treatment to prevention: The evolution of digital healthcare

An international perspective on the future of systemic sclerosis research

Identification of putative baroreceptors in human aortic arch by histological and omics analyses

LOTOS-based two-photon calcium imaging of dendritic spines in vivo

Biomarker dynamics and prognosis in breast cancer after neoadjuvant chemotherapy

Results of a worldwide survey on the currently used histopathological diagnostic criteria for invasive lobular breast cancer

Association between cardiovascular care and neurodevelopmental outcomes in infants with neonatal encephalopathy and hemodynamic instability

Repeated diagnostic ultrasound exposure modifies the structural properties of CA1 dendrites and alters the hippocampal transcriptome

Ki-67 assessment in early breast cancer: SAKK28/12 validation study on the IBCSG VIII and IBCSG IX cohort

Cessation of CCL2 inhibition accelerates breast cancer metastasis by promoting angiogenesis

The Hippo kinases LATS1 and 2 control human breast cell fate via crosstalk with ERα

Plasma neutrophil extracellular trap level is modified by disease severity and inhaled corticosteroids in chronic inflammatory lung diseases

Dual targeting of BCL-2 and MCL-1 in the presence of BAX breaks venetoclax resistance in human small cell lung cancer

The role of the Aspergillus nidulans high mobility group B protein HmbA, the orthologue of Saccharomyces cerevisiae Nhp6p

Early prediction of acute necrotizing pancreatitis by artificial intelligence: a prospective cohort-analysis of 2387 cases

Abnormal basement membrane results in increased keratinocyte-derived periostin expression in psoriasis similar to wound healing

Synthesis and biochemical evaluation of 17-N-beta-aminoalkyl-4,5α-epoxynormorphinans

A complete nicotinate degradation pathway in the microbial eukaryote Aspergillus nidulans

MATRIEX imaging: multiarea two-photon real-time in vivo explorer

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