Abstract
Two novel furaquinocin (FQ) analogues, I (1) and J (2), were isolated from Streptomyces reveromyceticus SN-593 strain NRM2. Their structures were elucidated by MS and NMR analyses. Similar to the previously described FQ D (3), both 1 and 2 possessed a dihydrofuran ring fused to a polyketide naphthoquinone skeleton. The main difference between 1, 2 and 3 was the type of residue attached to C-13; these were a carboxyl, a carboxamide and a methyl residue, respectively.
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Acknowledgements
We are grateful to Dr Y Futamura for cytoxicity assays. This work was supported in part by a Grant-in-Aid for Creative Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology of Japan.
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Panthee, S., Takahashi, S., Takagi, H. et al. Furaquinocins I and J: novel polyketide isoprenoid hybrid compounds from Streptomyces reveromyceticus SN-593. J Antibiot 64, 509–513 (2011). https://doi.org/10.1038/ja.2011.41
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DOI: https://doi.org/10.1038/ja.2011.41
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