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Reply to 'Corrected structure of mirin, a small-molecule inhibitor of the Mre11–Rad50–Nbs1 complex'

Nature Chemical Biology volume 5, page 130 (2009)Cite this article

Shaun Peterson et al. reply:

We recently identified mirin from a forward genetic screen of a 10,000-compound library from Chembridge Corporation1. The structure of mirin was assigned by the Chembridge database to be 6-(4-hydroxyphenyl)-2-thioxo-2,3-dihydro-4(1H)-pyrimidinone (Chembridge number 6451023, compound 1; note that for clarity we use the same compound numbering scheme as Garner, Pletnev and Eastman). Following the original screen, we obtained more compound from Chembridge to confirm the original finding and performed additional characterization of the inhibitor. During the course of our studies, Chembridge ran out of compound number 6451023. We identified another source for 6-(4-hydroxyphenyl)-2-thioxo-2,3-dihydro-4(1H)-pyrimidinone (Scientific Exchange, Inc.) and completed our studies with this compound. Notably, the compounds from Chembridge and Scientific Exchange had the same orange-red color and displayed similar activity in our assays. We did not realize until later that both companies had obtained this compound from the same source.

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References

  1. Dupré, A. et al. Nat. Chem. Biol. 4, 119–125 (2008).

    Article  Google Scholar 

  2. Irvine, M.W., Patrick, G.L., Kewney, J., Hastings, S.F. & MacKenzie, S.J. Bioorg. Med. Chem. Lett. 18, 2032–2037 (2008).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Institute for Cancer Genetics, Columbia University Medical Center, 1130 St. Nicholas Avenue, New York, 10032, New York, USA

    Shaun Peterson, Lily Wang, Kirsten Robertson & Jean Gautier

  2. Organic Synthesis Core Facility, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, Box 237, New York, 10065, New York, USA

    Geralda Torchon & Ouathek Ouerfelli

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  1. Shaun Peterson
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  2. Lily Wang
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Peterson, S., Wang, L., Robertson, K. et al. Reply to 'Corrected structure of mirin, a small-molecule inhibitor of the Mre11–Rad50–Nbs1 complex'. Nat Chem Biol 5, 130 (2009). https://doi.org/10.1038/nchembio0309-130

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