Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letters to the Editor
  • Published:

Adenovirus E1A and Ewing tumors

Abstract

In the December 1999 issue of Nature Medicine, Melot and Delattre1 and Kovar2, challenged the Sanchez-Prieto et al . September 1999 article3 proposing that the adenoviral E1A gene induces the Ewing tumor fusion transcript EWS–FLI1. Here Sanchez-Prieto et al. respond…Ed.

This is a preview of subscription content, access via your institution

Access options

Buy this article

USD 39.95

Prices may be subject to local taxes which are calculated during checkout

References

  1. Melot, T. & Delattre, O. E1A and the Ewing tumor translocation . Nature Med. 5, 1331 ( 1999).

    Article  CAS  Google Scholar 

  2. Kovar, H. E1A and the Ewing tumor translocation. Nature Med. 5, 1331 (1999).

    Article  CAS  Google Scholar 

  3. Sanchez-Prieto, R., et al. An association between viral genes and human oncogenic alterations: The adenovirus E1A induces the Ewing tumor fusion transcript EWS–FLI1 . Nature Med. 5, 1076–1081 (1999).

    Article  CAS  Google Scholar 

  4. Graham, F.L., Smiley, J., Russell, W.C. & Nairn, R. Characteristics of a human cell line transformed by DNA from human adenovirus type 5. J. Gen. Virol. 36, 59– 72 (1977).

    Article  CAS  Google Scholar 

  5. Caporossi, D. & Bacchetti, S. Definition of adenovirus type 5 functions involved in the induction of chromosomal aberrations in human cells. J. Gen. Virol. 71, 801– 808 (1990).

    Article  CAS  Google Scholar 

  6. Kirn, D. & Hermiston, T. Induction of an oncogenic fusion protein by a viral gene—a new chapter in an old story. Nature Med. 5, 991–992 ( 1999).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

de Alava, E., Sanchez-Prieto, R. & Ramon y Cajal, S. Adenovirus E1A and Ewing tumors. Nat Med 6, 4 (2000). https://doi.org/10.1038/71515

Download citation

  • Issue date:

  • DOI: https://doi.org/10.1038/71515

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing