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The flip side of cardiolipin import

Nature Medicine volume 17, page 413 (2011)Cite this article

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A Correspondence to this article was published on 07 April 2011

To the Editor:

We read with interest the paper by Ray and colleagues1 reporting that elevated cardiolipin levels during pulmonary infection impair lung and lung surfactant function. They suggest that Atp8B1 is a cardiolipin importer that helps clear this lipid from lung surfactant and that it contains a 40-amino-acid cardiolipin-binding domain that reduces lung injury when introduced into infected lungs. We do appreciate the inference that elevated cardiolipin contributes to the etiology of pneumonia and the observation that Atp8B1 overexpression improves lung function after experimental pneumonia. However, the mechanism of pulmonary cardiolipin accumulation and the role of Atp8B1 therein is not illuminated by the experiments of Ray and colleagues1.

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Authors and Affiliations

  1. Tytgat Institute for Liver and Intestinal Research, Academic Medical Center, Amsterdam, The Netherlands

    Coen C Paulusma

  2. Department of Pediatrics, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, The Netherlands

    Roderick H J Houwen

  3. Department of Biology, Amherst College, Amherst, Massachusetts, USA

    Patrick L Williamson

Authors
  1. Coen C Paulusma
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  2. Roderick H J Houwen
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  3. Patrick L Williamson
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Correspondence to Coen C Paulusma.

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The authors declare no competing financial interests.

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Paulusma, C., Houwen, R. & Williamson, P. The flip side of cardiolipin import. Nat Med 17, 413 (2011). https://doi.org/10.1038/nm0411-413a

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