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Reply to: “Being too inclusive about synuclein inclusions”

Nature Medicine volume 16, page 961 (2010)Cite this article

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Kordower, Halliday and Obeso reply:

We appreciate the opportunity to clarify a salient point in our recent review1. Drs. Isacson and Mendez are correct that the percentage of Lewy bodies in grafted neurons (5–8%) that we cited referred specifically to the findings of Kordower et al.2 and that it was not meant to refer to all of the papers referenced in the previous sentence. We are glad to clarify this point. It is interesting to note that Li et al.3 recently reported that 2% and 5% of grafted neurons contained Lewy bodies 12 and 15 years, respectively, after grafting, even though it is true that the cases reported by Mendez et al.4 contained far fewer Lewy bodies.

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References

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Authors and Affiliations

  1. Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, USA

    Jeffrey H Kordower

  2. Neuroscience Research Australia and the University of New South Wales, Randwick, Australia

    Glenda Halliday

  3. Department of Neurology, Clínica Universitaria and Medical School of Navarra, Neuroscience Centre, Center for Applied Medical Research, Universidad de Navarra, Pamplona, Spain

    Jose A Obeso

  4. Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Instituto Carlos III, Ministerio de Investigación y Ciencias, Spain

    Jose A Obeso

Authors
  1. Jeffrey H Kordower
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  2. Glenda Halliday
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  3. Jose A Obeso
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Corresponding author

Correspondence to Jose A Obeso.

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The authors declare no competing financial interests.

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Kordower, J., Halliday, G. & Obeso, J. Reply to: “Being too inclusive about synuclein inclusions”. Nat Med 16, 961 (2010). https://doi.org/10.1038/nm0910-961a

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