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Alzheimer disease

Plasma lipid biomarkers for early-stage Alzheimer disease

Nature Reviews Neurology volume 7, page 474 (2011)Cite this article

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Changes in lipids in the brain have previously been associated with Alzheimer disease (AD). Now, an interdisciplinary team have used a multimodality lipidomics technique to measure hundreds of lipids simultaneously, and found significant changes in plasma lipids that are associated with the early stages of AD.

Animal models and postmortem analyses have identified alterations in specific brain lipids that are associated with the early stages of AD. Metabolomics—analysis of small molecules in cells and tissues—can characterize global signals of disease, but measurement in the brain is difficult, whereas peripheral plasma biomarkers are relatively easy to monitor.

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ORIGINAL RESEARCH PAPER

  1. Han, X. et al. Metabolomics in early Alzheimer's disease: identification of altered plasma shingolipidome using shotgun lipidomics. PLoS ONE 6, e21643 (2011)

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  1. Eleanor Beal
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Beal, E. Plasma lipid biomarkers for early-stage Alzheimer disease. Nat Rev Neurol 7, 474 (2011). https://doi.org/10.1038/nrneurol.2011.125

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