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Continuous glucose monitoring in neonates: challenges and opportunities

Journal of Perinatology volume 44, pages 1382–1383 (2024)Cite this article

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Continuous glucose monitoring (CGM) has the potential to improve glucose stability. However, caution is required before this technology can be adopted into clinical practice as data are still limited in neonates.

We congratulate Patel et al. for pursuing important research in neonatal hypoglycemia. They assessed the accuracy of the Dexcom G6 CGM in a population of 33 term/late pre-term newborns at risk of hypoglycemia during the first days after birth. This study showed a mean absolute relative difference (MARD) of 43.5% with an estimated bias of CGM vs. i-STAT of 23.6 mg/dL. Therefore, the authors concluded that the use of CGM was not accurate and could not be reliably used as a trending device [1].

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Fig. 1: CGM accuracy in infants with hypoxic ischemic encephalopathy.

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All data relevant to the study are included in the article.

References

  1. Patel NS, Duke RP, Tian Z, Zhou S, Kaiser JR. Agreement between intermittent glucose concentrations and continuous glucose monitoring in at-risk newborns. J Perinatol. 2024. https://doi.org/10.1038/s41372-024-01906-6. Online ahead of print.

  2. Reiterer F, Polterauer P, Schoemaker M, Schmelzeisen-Redecker G, Freckmann G, Heinemann L, et al. Significance and reliability of MARD for the accuracy of CGM systems. J Diabetes Sci Technol. 2017;11:59–67.

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Authors and Affiliations

  1. Department of Woman, Child, and General and Specialized Surgery, University of Campania “Luigi Vanvitelli,”, Naples, Italy

    Simona Puzone, Mario Diplomatico & Paolo Montaldo

  2. Department of Neonatal Intensive Care, AORN San Giuseppe Moscati, Avellino, Italy

    Mario Diplomatico

  3. Department of Pediatrics, Pediatric Endocrinology, Yale University, New Haven, CT, USA

    Alfonso Galderisi

  4. Centre for Perinatal Neuroscience, Imperial College London, London, UK

    Paolo Montaldo

Authors
  1. Simona Puzone
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  2. Mario Diplomatico
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  3. Alfonso Galderisi
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  4. Paolo Montaldo
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Contributions

SP analyzed data, interpreted results, and drafted the manuscript. AG and MD assisted in conceptualizing and designing the study. PM conceived the idea, assisted with developing the manuscript, and supervised the entire work. All authors critically revised the intellectual content of the manuscript.

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Correspondence to Paolo Montaldo.

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Puzone, S., Diplomatico, M., Galderisi, A. et al. Continuous glucose monitoring in neonates: challenges and opportunities. J Perinatol 44, 1382–1383 (2024). https://doi.org/10.1038/s41372-024-02041-y

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