Fig. 1: IV-administration of glycerol reduced diabetic ketosis induced by empagliflozin.
From: Non-carbohydrate anaplerotic therapy counters empagliflozin-induced diabetic ketosis
Diabetic sheep were pre-induced into moderate ketosis via empagliflozin and insulin withdrawal. Bolus IV infusions of 1 L 5% glycerol (solid line) or saline (dotted line) were administered, with blood BHB (A) and glucose (B) levels monitored repeatedly over 5 h. The reduction in ketosis (BHB) peaked approximately 1 h post-treatment, while the increase in blood glucose peaked within around 4 h. The statistical analyses are presented in Table 1.
