Table 1 Ferroptosis inducers that work against CRPC.
Classification | Compound | Target | Cell line | Mechanism |
|---|---|---|---|---|
Class I | Erastin | SLC7A11 | DU145, PC3, 22Rv1, LNCaP, NCI-H660, ARCaP, C4-2, and LNCaP | Inhibit SLC7A11 activity |
AR and SLC7A11 | 22Rv1, LNCaP95 | Reduction of the expression and transcriptional activity of AR, AR-V7 and GPX4 | ||
Buthionine Sulphoximine (BSO) | GSH | VCaP, 22Rv1 | Inhibit GSH synthesis | |
Class II | RSL3 | GPX4 | LNCaP, 22RV1, C4-2B, DuCaP | Inhibit GPX4 activity |
Class III | FIN56 | CoQ, GPX4 | LNCaP, VCaP, 22Rv1 | Deplete CoQ and degrade GPX4 |
