Table 2 Hazard ratio (95% CI) and P-value of MACE for factors in univariate and multivariable analysis.

From: Real-world analyses of major adverse cardiovascular events and mortality risk after androgen deprivation therapy initiation in black vs. white prostate cancer patients

Factors

Univariable

Multivariable (N = 27,398b,c,d)

n

HR (95% CI)

P-value

HR (95% CI)

P-value

BMI < 18.5 vs ≥18.5 (kg/m2)

34,861b,c

2.29 (1.82–2.90)

<0.001

2.45 (1.87–3.22)

<0.001

White vs Black (Race)

33,891b,d

1.69 (1.56–1.82)

<0.001

1.72 (1.56–1.89)

<0.001

  1. MACE risk was higher for White vs. Black patients and patients with BMI <18.5 vs. BMI ≥18.5 kg/m2. BMI and race are largely independent and do not account for the other factor’s increased MACE risk.
  2. CI Confidence interval, MACE Major adverse cardiovascular events, HR Hazard ratio, BMI Body mass index.
  3. aMACE (recent urology studies HERO and PRONOUNCE definition) defined as myocardial infarction, stroke, and mortality from any cause.
  4. bExcluded patients who had a MACE <6 months prior to ADT Start.
  5. cExcluded patients without BMI data.
  6. dExcluded patients who were not of white or black race.
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