Fig. 4: Heterodimers of caspase-8 D387A and cFLIP mediate TNF-induced apoptosis. | Cell Death & Differentiation

Fig. 4: Heterodimers of caspase-8 D387A and cFLIP mediate TNF-induced apoptosis.

From: cFLIP suppresses caspase-1- and MLKL-independent perinatal lethality driven by auto-processing impaired caspase-8 D387A

Fig. 4: Heterodimers of caspase-8 D387A and cFLIP mediate TNF-induced apoptosis.

a Percentage of surviving MEFs at 24 h after treatment. Bars indicate the mean. Circles, cells from individual embryos (n = 3 per genotype). T, 100 ng/mL TNF. B, 2 μM BV6. G, 10 μM GSK843. E, 20 μM emricasan. PI, propidium iodide. b–f Western blots of primary MEFs or their immunoprecipitates (IP). NTC, non-targeting control sgRNA. Lanes (c, d), cells from individual embryos. Results in (b, e, f) representative of 2 independent experiments.

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