Fig. 5: FADD-dependent NF-κB activation and chemokine expression in Casp81xDA/1xDA Cflar-/- MEFs. | Cell Death & Differentiation

Fig. 5: FADD-dependent NF-κB activation and chemokine expression in Casp81xDA/1xDA Cflar-/- MEFs.

From: cFLIP suppresses caspase-1- and MLKL-independent perinatal lethality driven by auto-processing impaired caspase-8 D387A

Fig. 5: FADD-dependent NF-κB activation and chemokine expression in Casp81xDA/1xDA Cflar-/- MEFs.

a Volcano plot indicates differentially expressed genes in Casp81xDA/1xDA Cflar-/- Mlkl-/- MEFs compared with Mlkl-/- MEFs (n = 3 per genotype). Red dots, upregulated genes. FC, fold change. FDR, false discovery rate. b Graphs (top) show relative Ccl5 and Cxcl10 transcript levels in MEFs characterized by western blot (bottom). Bars indicate the mean. Circles, MEFs from individual embryos. c Western blots of E18.5 intestines. Lanes, individual embryos.

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