Fig. 6: Casp8^1xDA/1xDA Cflar^-/- Mlkl^-/- Fadd^-/- mice develop splenomegaly and lymphadenopathy.

a Kaplan–Meier curves of mouse survival. b Western blots of E18.5 mouse intestines. Lanes, individual embryos. c Lymph nodes and spleens from mice aged 8 weeks. Results representative of 4 Casp8^1xDA/1xDA Cflar^-/- Mlkl^-/- Fadd^-/-, 3 Casp8^{+/1xDA or +/+} Cflar^{+/- or +/+} Mlkl^-/- Fadd^+/-, and 3 Casp8^+/1xDA Cflar^+/- Casp1^{+/- or +/+} Mlkl^-/- Fadd^-/- mice aged 7–8 weeks. d Spleen weights and leukocyte numbers (spleen or brachial, axillary, inguinal, and mesenteric lymph nodes) of the mice in (c). Bars indicate the mean. Circles, individual mice. e Representative dot plots of lymph node cells from the mice in (c). Percentages, mean ± s.e.m.