Fig. 4: The RIPK3D143N mutation rescues Caspase-8-deficient mice from embryonic lethality. | Cell Death & Differentiation

Fig. 4: The RIPK3D143N mutation rescues Caspase-8-deficient mice from embryonic lethality.

From: The kinase domain of RIPK3 tunes its scaffolding functions

Fig. 4

A The number of neonates (genotyped at P1-P5) from seven heterozygous Casp8+/–Mlkl+/–Ripk3WT/D143N matings on C57BL/6 J background. Alleles annotated by a question mark (?) were either the wild-type (+) or the knock-out (–) allele. B Photo of Casp8+/+Mlkl+/–Ripk3WT/WT and Casp8–/–Mlkl+/–Ripk3D143N/D143N littermates at 3 days of age.

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