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The parkin-γ-tubulin axis regulates epidermal homeostasis and is associated with the susceptibility to psoriasis

Cell Death & Differentiation (2026)Cite this article

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Abstract

Psoriasis is an inflammatory skin disease marked by excessive proliferation of keratinocytes, and there is accumulating evidence indicating its association with Parkinson’s disease (PD). However, the molecular link between these two diseases remains elusive. Herein, we identify a potential role for parkin, a PD-related E3 ubiquitin ligase, in the inhibition of psoriasis pathogenesis. The level of parkin is reduced in psoriatic skin both in clinical samples and in mouse models. Parkin-deficient mice exhibit epidermal hyperplasia, increased keratinocyte proliferation, and enhanced susceptibility to psoriasis. Mechanistically, parkin interacts with γ-tubulin, a centrosomal protein required for microtubule organization, and mediates γ-tubulin ubiquitination and proteasomal degradation. Reduction of parkin in psoriatic skin leads to abnormal accumulation of γ-tubulin and disrupts the proper organization of microtubules in the epidermis, resulting in the hyperproliferation of keratinocytes. These findings reveal a previously unrecognized role for parkin in epidermal physiology and pathology, and offer novel insights into the crosstalk between psoriasis and PD.

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Fig. 1: Parkin is reduced in psoriatic skin both in clinical samples and in mouse models.
Fig. 2: Park2 knockout mice are more susceptible to psoriasis.
Fig. 3: Parkin deficiency results in abnormal γ-tubulin accumulation in keratinocytes.
Fig. 4: Parkin interacts with γ-tubulin both in cells and in vitro.
Fig. 5: Parkin mediates K48-linked ubiquitination of γ-tubulin to stimulate its proteasomal degradation.
Fig. 6: Parkin deficiency blocks the decrease of centrosomal MTOC activity to stimulate keratinocyte hyperproliferation.
Fig. 7: A schematic model showing the regulation of epidermal homeostasis by the parkin-γ-tubulin axis.

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Data availability

The mass spectrometry-based proteomics data for proteins differentially expressed in wild-type and Park2 knockout mice have been deposited to the ProteomeXchange Consortium (https://proteomecentral.proteomexchange.org) via the iProX partner repository [67, 68].

References

  1. Bouwstra JA, Nădăban A, Bras W, McCabe C, Bunge A, Gooris GS. The skin barrier: An extraordinary interface with an exceptional lipid organization. Prog Lipid Res. 2023;92:101252.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Moreci RS, Lechler T. Epidermal structure and differentiation. Curr Biol. 2020;30:R144–9.

    Article  CAS  PubMed  Google Scholar 

  3. Muroyama A, Seldin L, Lechler T. Divergent regulation of functionally distinct γ-tubulin complexes during differentiation. J Cell Biol. 2016;213:679–92.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Hlavaty D, Lechler T. Roles for microtubules in the proliferative and differentiated cells of stratified epithelia. Curr Opin Cell Biol. 2021;68:98–104.

    Article  CAS  PubMed  Google Scholar 

  5. Griffiths CEM, Armstrong AW, Gudjonsson JE, Barker J. Psoriasis. Lancet. 2021;397:1301–15.

    Article  CAS  PubMed  Google Scholar 

  6. Blauvelt A, Gooderham M, Iversen L, Ball S, Zhang L, Agada NO, et al. Efficacy and safety of ixekizumab for the treatment of moderate-to-severe plaque psoriasis: results through 108 weeks of a randomized, controlled phase 3 clinical trial (UNCOVER-3). J Am Acad Dermatol. 2017;77:855–62.

    Article  CAS  PubMed  Google Scholar 

  7. Gordon KB, Strober B, Lebwohl M, Augustin M, Blauvelt A, Poulin Y, et al. Efficacy and safety of risankizumab in moderate-to-severe plaque psoriasis (UltIMMa-1 and UltIMMa-2): results from two double-blind, randomised, placebo-controlled and ustekinumab-controlled phase 3 trials. Lancet. 2018;392:650–61.

    Article  CAS  PubMed  Google Scholar 

  8. Guo J, Zhang H, Lin W, Lu L, Su J, Chen X. Signaling pathways and targeted therapies for psoriasis. Signal Transduct Target Ther. 2023;8:437.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Cargill M, Schrodi SJ, Chang M, Garcia VE, Brandon R, Callis KP, et al. A large-scale genetic association study confirms IL12B and leads to the identification of IL23R as psoriasis-risk genes. Am J Hum Genet. 2007;80:273–90.

    Article  CAS  PubMed  Google Scholar 

  10. Hüffmeier U, Uebe S, Ekici AB, Bowes J, Giardina E, Korendowych E, et al. Common variants at TRAF3IP2 are associated with susceptibility to psoriatic arthritis and psoriasis. Nat Genet. 2010;42:996–9.

    Article  PubMed  PubMed Central  Google Scholar 

  11. Marek-Jozefowicz L, Czajkowski R, Borkowska A, Nedoszytko B, Żmijewski MA, Cubała WJ, et al. The brain-skin axis in psoriasis-psychological, psychiatric, hormonal, and dermatological aspects. Int J Mol Sci. 2022;23:669.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Wang X, Li Y, Wu L, Xiao S, Ji Y, Tan Y, et al. Dysregulation of the gut-brain-skin axis and key overlapping inflammatory and immune mechanisms of psoriasis and depression. Biomed Pharmacother. 2021;137:111065.

    Article  CAS  PubMed  Google Scholar 

  13. Quevedo ME, Slominski A, Pinto W, Wei E, Wortsman J. Pleiotropic effects of corticotropin releasing hormone on normal human skin keratinocytes. In Vitro Cell Dev Biol Anim. 2001;37:50–4.

    Article  CAS  PubMed  Google Scholar 

  14. Connor CJ, Liu V, Fiedorowicz JG. Exploring the physiological link between psoriasis and mood disorders. Dermatol Res Pract. 2015;2015:409637.

    Article  PubMed  PubMed Central  Google Scholar 

  15. Marogianni C, Sokratous M, Dardiotis E, Hadjigeorgiou GM, Bogdanos D, Xiromerisiou G. Neurodegeneration and inflammation-an interesting interplay in Parkinson’s disease. Int J Mol Sci. 2020;21:8421.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  16. Tansey MG, Wallings RL, Houser MC, Herrick MK, Keating CE, Joers V. Inflammation and immune dysfunction in Parkinson disease. Nat Rev Immunol. 2022;22:657–73.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  17. Su C, Huang T, Zhang M, Zhang Y, Zeng Y, Chen X. Glucocorticoid receptor signaling in the brain and its involvement in cognitive function. Neural Regen Res. 2025;20:2520–37.

    Article  CAS  PubMed  Google Scholar 

  18. van den Heuvel LL, du Plessis S, Stalder T, Acker D, Kirschbaum C, Carr J, et al. Hair glucocorticoid levels in Parkinson’s disease. Psychoneuroendocrinology. 2020;117:104704.

    Article  PubMed  Google Scholar 

  19. Lee JH, Han K, Gee HY. The incidence rates and risk factors of Parkinson disease in patients with psoriasis: A nationwide population-based cohort study. J Am Acad Dermatol. 2020;83:1688–95.

    Article  CAS  PubMed  Google Scholar 

  20. Li C, Li X, Lin J, Cui Y, Shang H. Psoriasis and progression of Parkinson’s disease: a Mendelian randomization study. J Eur Acad Dermatol Venereol. 2022;36:2401–5.

    Article  CAS  PubMed  Google Scholar 

  21. McWilliams TG, Barini E, Pohjolan-Pirhonen R, Brooks SP, Singh F, Burel S, et al. Phosphorylation of Parkin at serine 65 is essential for its activation in vivo. Open Biol. 2018;8:180108.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  22. Bloem BR, Okun MS, Klein C. Parkinson’s disease. Lancet. 2021;397:2284–2303.

    Article  CAS  PubMed  Google Scholar 

  23. Morris HR, Spillantini MG, Sue CM, Williams-Gray CH. The pathogenesis of Parkinson’s disease. Lancet. 2024;403:293–304.

    Article  CAS  PubMed  Google Scholar 

  24. Han R, Wang Q, Xiong X, Chen X, Tu Z, Li B, et al. Deficiency of parkin causes neurodegeneration and accumulation of pathological α-synuclein in monkey models. J Clin Invest. 2024;134:e179633.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  25. Yue RZ, Guo X, Li CJ, Wu LJ, Liu YT, Hu J, et al. Upregulated astrocytic HDAC7 induces depression-like disorders via deacetylating PINK1 and inhibiting mitophagy. J Neuroinflammation. 2025;22:276.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  26. Yanli M, Yu W, Yuzhen L. Elevated SIRT3 Parkin-dependently activates cell mitophagy to ameliorate TNF-α-induced psoriasis-related phenotypes in HaCaT cells through deacetylating FOXO3a for its activation. Arch Dermatol Res. 2023;315:847–57.

    Article  PubMed  Google Scholar 

  27. Shen H, Sha Y, Huang J, Mao AQ, Zhang T, Wu MY, et al. The roles of AMPK-mediated autophagy and mitochondrial autophagy in a mouse model of imiquimod-induced psoriasis. Am J Transl Res. 2021;13:12626–37.

    CAS  PubMed  PubMed Central  Google Scholar 

  28. Zheng J, Yao L, Zhou Y, Gu X, Wang C, Bao K, et al. A novel function of NLRP3 independent of inflammasome as a key transcription factor of IL-33 in epithelial cells of atopic dermatitis. Cell Death Dis. 2021;12:871.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  29. Ciążyńska M, Bednarski IA, Wódz K, Narbutt J, Lesiak A. NLRP1 and NLRP3 inflammasomes as a new approach to skin carcinogenesis. Oncol Lett. 2020;19:1649–56.

    PubMed  PubMed Central  Google Scholar 

  30. Shirley SN, Watson AE, Yusuf N. Pathogenesis of inflammation in skin disease: from molecular mechanisms to pathology. Int J Mol Sci. 2024;25:10152.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  31. Swatek KN, Komander D. Ubiquitin modifications. Cell Res. 2016;26:399–422.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  32. Yau R, Rape M. The increasing complexity of the ubiquitin code. Nat Cell Biol. 2016;18:579–86.

    Article  CAS  PubMed  Google Scholar 

  33. Meyer HJ, Rape M. Enhanced protein degradation by branched ubiquitin chains. Cell. 2014;157:910–21.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  34. Kolla S, Ye M, Mark KG, Rapé M. Assembly and function of branched ubiquitin chains. Trends Biochem Sci. 2022;47:759–71.

    Article  CAS  PubMed  Google Scholar 

  35. Zhao J, Ren Y, Jiang Q, Feng J. Parkin is recruited to the centrosome in response to inhibition of proteasomes. J Cell Sci. 2003;116:4011–9.

    Article  CAS  PubMed  Google Scholar 

  36. Jiang Q, Ren Y, Feng J. Direct binding with histone deacetylase 6 mediates the reversible recruitment of parkin to the centrosome. J Neurosci. 2008;28:12993–3002.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  37. Zhang Y, Gao J, Chung KK, Huang H, Dawson VL, Dawson TM. Parkin functions as an E2-dependent ubiquitin- protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1. Proc Natl Acad Sci USA. 2000;97:13354–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  38. Panicker N, Kam TI, Wang H, Neifert S, Chou SC, Kumar M, et al. Neuronal NLRP3 is a parkin substrate that drives neurodegeneration in Parkinson’s disease. Neuron. 2022;110:2422–37.e2429.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  39. Shimura H, Schlossmacher MG, Hattori N, Frosch MP, Trockenbacher A, Schneider R, et al. Ubiquitination of a new form of alpha-synuclein by parkin from human brain: implications for Parkinson’s disease. Science. 2001;293:263–9.

    Article  CAS  PubMed  Google Scholar 

  40. Han R, Wang Q, Xiong X, Chen X, Tu Z, Li B, et al. Deficiency of parkin causes neurodegeneration and accumulation of pathological α-synuclein in monkey models. J Clin Invest 2024;134:e179633.

  41. Chung KK, Zhang Y, Lim KL, Tanaka Y, Huang H, Gao J, et al. Parkin ubiquitinates the alpha-synuclein-interacting protein, synphilin-1: implications for Lewy-body formation in Parkinson disease. Nat Med. 2001;7:1144–50.

    Article  CAS  PubMed  Google Scholar 

  42. Imai Y, Soda M, Inoue H, Hattori N, Mizuno Y, Takahashi R. An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin. Cell. 2001;105:891–902.

    Article  CAS  PubMed  Google Scholar 

  43. Ren Y, Zhao J, Feng J. Parkin binds to alpha/beta tubulin and increases their ubiquitination and degradation. J Neurosci. 2003;23:3316–24.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  44. Yang F, Jiang Q, Zhao J, Ren Y, Sutton MD, Feng J. Parkin stabilizes microtubules through strong binding mediated by three independent domains. J Biol Chem. 2005;280:17154–62.

    Article  CAS  PubMed  Google Scholar 

  45. Starita LM, Machida Y, Sankaran S, Elias JE, Griffin K, Schlegel BP, et al. BRCA1-dependent ubiquitination of gamma-tubulin regulates centrosome number. Mol Cell Biol. 2004;24:8457–66.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  46. Sankaran S, Crone DE, Palazzo RE, Parvin JD. BRCA1 regulates gamma-tubulin binding to centrosomes. Cancer Biol Ther. 2007;6:1853–7.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  47. Lin TC, Neuner A, Schlosser YT, Scharf AN, Weber L, Schiebel E. Cell-cycle dependent phosphorylation of yeast pericentrin regulates γ-TuSC-mediated microtubule nucleation. Elife. 2014;3:e02208.

    Article  PubMed  PubMed Central  Google Scholar 

  48. Vogel J, Drapkin B, Oomen J, Beach D, Bloom K, Snyder M. Phosphorylation of gamma-tubulin regulates microtubule organization in budding yeast. Dev Cell. 2001;1:621–31.

    Article  CAS  PubMed  Google Scholar 

  49. Wang GF, Dong Q, Bai Y, Gu J, Tao Q, Yue J, et al. c-Abl kinase-mediated phosphorylation of γ-tubulin promotes γ-tubulin ring complexes assembly and microtubule nucleation. J Biol Chem. 2022;298:101778.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  50. Jung BC, Kim SH, Cho Y, Kim YS. Tumor suppressor Parkin induces p53-mediated cell cycle arrest in human lung and colorectal cancer cells. BMB Rep. 2023;56:557–62.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  51. Zhong T, Wu X, Xie W, Luo X, Song T, Sun S, et al. ENKD1 promotes epidermal stratification by regulating spindle orientation in basal keratinocytes. Cell Death Differ. 2022;29:1719–29.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  52. Sun S, Wang Z, Xu Z, Wang Z, Sun J, Li K, et al. CFAP100 couples microtubule glutamylation to spindle pole integrity in keratinocytes to promote epidermal development. Nat Commun. 2025;16:5591.

    Article  PubMed  PubMed Central  Google Scholar 

  53. Lingle WL, Barrett SL, Negron VC, D’Assoro AB, Boeneman K, Liu W, et al. Centrosome amplification drives chromosomal instability in breast tumor development. Proc Natl Acad Sci USA. 2002;99:1978–83.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  54. Lopes D, Maiato H. The tubulin code in mitosis and cancer. Cells. 2020;9:2356.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  55. Denison SR, Wang F, Becker NA, Schüle B, Kock N, Phillips LA, et al. Alterations in the common fragile site gene Parkin in ovarian and other cancers. Oncogene. 2003;22:8370–8.

    Article  CAS  PubMed  Google Scholar 

  56. Ikeuchi K, Marusawa H, Fujiwara M, Matsumoto Y, Endo Y, Watanabe T, et al. Attenuation of proteolysis-mediated cyclin E regulation by alternatively spliced Parkin in human colorectal cancers. Int J Cancer. 2009;125:2029–35.

    Article  CAS  PubMed  Google Scholar 

  57. Su Q, Wang JJ, Ren JY, Wu Q, Chen K, Tu KH, et al. Parkin deficiency promotes liver cancer metastasis by TMEFF1 transcription activation via TGF-β/Smad2/3 pathway. Acta Pharmacol Sin. 2024;45:1520–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  58. Ye G, Sun X, Li J, Pu M, Zhang J Parkin modulates the hepatocellular carcinoma microenvironment by regulating PD-1/PD-L1 signalling. J Adv Res 2025;76:731–44

  59. Fujiwara M, Marusawa H, Wang HQ, Iwai A, Ikeuchi K, Imai Y, et al. Parkin as a tumor suppressor gene for hepatocellular carcinoma. Oncogene. 2008;27:6002–11.

    Article  CAS  PubMed  Google Scholar 

  60. Scharadin TM, Jiang H, Jans R, Rorke EA, Eckert RL. TIG3 tumor suppressor-dependent organelle redistribution and apoptosis in skin cancer cells. PLoS One. 2011;6:e23230.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  61. Zhao JY, Yuan XK, Luo RZ, Wang LX, Gu W, Yamane D, et al. Phospholipase A and acyltransferase 4/retinoic acid receptor responder 3 at the intersection of tumor suppression and pathogen restriction. Front Immunol. 2023;14:1107239.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  62. Scharadin TM, Eckert RL. TIG3: an important regulator of keratinocyte proliferation and survival. J Invest Dermatol. 2014;134:1811–6.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  63. Duvic M, Helekar B, Schulz C, Cho M, DiSepio D, Hager C, et al. Expression of a retinoid-inducible tumor suppressor, Tazarotene-inducible gene-3, is decreased in psoriasis and skin cancer. Clin Cancer Res. 2000;6:3249–59.

    CAS  PubMed  Google Scholar 

  64. Venkataswamy P, Samudrala Venkatesiah S, Rao RS, Banavar SR, Patil S, Augustine D, et al. Immunohistochemical expression of Tazarotene-induced Gene 3 in oral squamous cell carcinoma. J Oral Pathol Med. 2021;50:403–9.

    Article  CAS  PubMed  Google Scholar 

  65. Sturniolo MT, Dashti SR, Deucher A, Rorke EA, Broome AM, Chandraratna RA, et al. A novel tumor suppressor protein promotes keratinocyte terminal differentiation via activation of type I transglutaminase. J Biol Chem. 2003;278:48066–73.

    Article  CAS  PubMed  Google Scholar 

  66. Lian N, Chen Y, Chen S, Zhang Y, Chen H, Yang Y, et al. Gasdermin D-mediated keratinocyte pyroptosis as a key step in psoriasis pathogenesis. Cell Death Dis. 2023;14:595.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  67. Ma J, Chen T, Wu S, Yang C, Bai M, Shu K, et al. iProX: an integrated proteome resource. Nucleic Acids Res. 2019;47:D1211–7.

    Article  PubMed  PubMed Central  Google Scholar 

  68. Chen T, Ma J, Liu Y, Chen Z, Xiao N, Lu Y, et al. iProX in 2021: connecting proteomics data sharing with big data. Nucleic Acids Res. 2022;50:D1522–7.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Acknowledgements

This work was supported by grants from the National Natural Science Foundation of China (32230025) and the National Key R&D Program of China (2021YFA1101001).

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Authors and Affiliations

  1. Center for Cell Structure and Function, College of Life Sciences, Shandong Normal University, Jinan, China

    Yuanyuan Liu, Shaoze Yan, Jiaxuan Wang, Min Liu, Jinmin Gao & Jun Zhou

  2. Department of Clinical Pathobiology and Immunological Testing, School of Medical Laboratory, Qilu Medical University, Zibo, China

    Yuanyuan Liu

  3. Department of Genetics and Cell Biology, College of Life Sciences, State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin, China

    Dan Dong, Shaodong Yan, Hanxiao Yin, Kai Liu, Dengwen Li, Jinmin Gao & Jun Zhou

  4. Hospital for Skin Diseases, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, China

    Hong Liu

  5. Medical Science and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, China

    Wei Xie

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  1. Yuanyuan Liu
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Contributions

J.Z. supervised the project. Y.L., W.X., and J.Z. designed the experiments. Y.L., Shaoze Y., J.W., D.D., Shaodong Y., H.Y., and K.L. performed the experiments. Y.L., M.L., D.L., J.G., W.X., and J.Z. analyzed the data. H.L. provided clinical samples. Y.L., W.X., and J.Z. wrote the manuscript.

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Correspondence to Wei Xie or Jun Zhou.

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Liu, Y., Yan, S., Wang, J. et al. The parkin-γ-tubulin axis regulates epidermal homeostasis and is associated with the susceptibility to psoriasis. Cell Death Differ (2026). https://doi.org/10.1038/s41418-026-01693-x

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