Abstract
Two new cytotoxic antibiotics designated quinomycins H1 (2) and H2 (3) were isolated from the culture broth of Streptomyces sp. RAL404. The molecular formula of both compounds was established as C52H65N11O13S2 by electrospray ionization mass spectrometry (ESI-MS). Their structures were determined as echinomycin (1) derivatives containing a 3-hydoxyquinaldic acid molecule in place of one of the two quinoxaline-2-carboxylic acid chromophores. Quinomycins H1 (2) and H2 (3) showed selective cytotoxicity against RG-E1-4 cells bearing the adenovirus oncogenes with IC50s of 11 nM and 12 nM, respectively.
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We are grateful to Ms. F. Hasegawa for assistance with mass spectrometry.
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Hayakawa, Y., Sone, R., Aoki, H. et al. Quinomycins H1 and H2, new cytotoxic antibiotics from Streptomyces sp. RAL404. J Antibiot 71, 898–901 (2018). https://doi.org/10.1038/s41429-018-0083-6
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DOI: https://doi.org/10.1038/s41429-018-0083-6
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