Table 2 Baseline values of haematological parameters and vitamin B12/folate (mean [SD])

From: The effect of vitamin B12 and folic acid supplementation on routine haematological parameters in older people: an individual participant data meta-analysis

Author

 

Intervention group

Control group

Studies on B12

Dangour [28]

Haemoglobin (g/dL)

14.0 (1.1)

13.8 (1.2)

 

Haematocrit (fraction)

41 (3)

41 (3)

 

Anaemic individuals (n)

3 of 80

10 of 75

 

Vitamin B12 (pmol/L)

232 [52]

237 [60]

 

B12 deficiency (n)

3 of 80

4 of 75

Favrat [29]

Haematocrit (fraction)

40.4 (3.9)

39.8 (4.6)

 

Anaemic individuals (n)

10 of 23

7 of 22

 

Vitamin B12 (pmol/L)

167 (23)

155 (20)

 

B12 deficiency (n)

8 of 23

12 of 22

Hvas [30]

Haemoglobin (g/dL)

13.1 (1.4)

13.5 (1.2)

 

Anaemic individuals (n)

16 of 67

12 of 70

 

Vitamin B12 (pmol/L)

303 (159)

277 [92]

 

B12 deficiency (n)

1 of 67

1 of 70

Seal [31, 1]

Haemoglobin (g/dL)

12.4 (1.4)

13.2 (1.3)

 

Anaemic individuals (n)

6 of 12

4 of 14

 

Vitamin B12 (pmol/L)

135 (27)

143 (21)

 

B12 deficiency (n)

9 of 12

7 of 14

Seal [31, 2]

Haemoglobin (g/dL)

13.2 (1.7)

13.2 (1.3)

 

Anaemic individuals (n)

4 of 14

4 of 14

 

Vitamin B12 (pmol/L)

153 [39]

143 (21)

 

B12 deficiency (n)

10 of 14

7 of 14

Studies on folic acid

Durga [32]

Haemoglobin (g/dL)

14.2 (1.1)

14.3 (1.1)

 

Haematocrit (fraction)

44 (4)

44 (4)

 

Anaemic individuals (n)

22 of 395

21 of 407

 

Folate (nmol/l)

12.4 (4.3)

12.6 (4.6)

 

Folate deficiency (n)

24 of 395

30 of 407

Pathansali [33]

Haemoglobin (g/dL)

13.2 (0.9)

13.0 (0.9)

 

Haematocrit (fraction)

40 (2)

40 (2)

 

Anaemic individuals (n)

3 of 12

2 of 12

 

Folate (nmol/l)

13.8 (5.0)

15.0 (6.0)

 

Folate deficiency (n)

9 of 12

7 of 12

Ntaios [34]

Haemoglobin (g/dL)

13.9 (0.7)

14.2 (1.2)

 

Haematocrit (fraction)

42 (2)

43 (4)

 

Anaemic individuals (n)

4 of 53

2 of 50

 

Folate (nmol/l)

19.9 (8.7)

18.2 (6.1)

 

Folate deficiency (n)

0 of 53

0 of 50

  1. Anaemia defined as haemoglobin <12 g/dL (haematocrit <0.4%) for male and <13 g/dL (haematocrit <0.35%) for female individuals
  2. Vitamin B12 deficiency defined as B12 <150 pmol/l
  3. Folate deficiency defined as folate <7 nmol/l