Table 3 Effect of vitamin B12 and folic acid supplementation on haematological parameters

From: The effect of vitamin B12 and folic acid supplementation on routine haematological parameters in older people: an individual participant data meta-analysis

 

Vitamin B12

Folic acid

Outcome

 

N

Mean baseline (SD)

Mean difference

[95% CI]

Weight (%)

 

N

Mean baseline (SD)

Mean difference

[95% CI]

Weight (%)

Haemoglobin (g/dL)

Dangour

155

13.9 (1.2)

−0.01

[−0.26; 0.25]

51.9

Durga

802

14.3 (1.1)

−0.07

[−0.18; 0.04]

83.2

Favrat

0

Pathansali

24

13.1 (0.9)

0.00

[−0.47; 0.47]

4.6

Hvas

137

13.3 (1.3)

0.01

[−0.27; 0.29]

41.6

Ntaios

103

14.0 (1.0)

−0.22

[−0.51; 0.07]

12.3

Seal 1

25

12.8 (1.4)

0.20

[−0.65; 1.05

4.6

      

Seal 2

26

13.2 (1.5)

−0.62

[−1.97; 0.72]

1.9

      

Pooled estimate (I2 = 0%)

343

 

0.00

[−0.19; 0.18]

100

Pooled estimate (I2 = 0%)

929

 

−0.09

[−0.19; 0.01]

100

Haematocrit (fraction)

Dangour

155

0.41 (0.03)

0.00

[−0.01; 0.01]

77.0

Durga

802

0.44 (0.04)

0.00

[−0.01; 0]

70.0

Favrat

45

0.40 (0.04)

0.00

[−0.01; 0.01]

23.0

Pathansali

18

0.40 (0.02)

0.00

[−0.01; 0.02]

5.6

Hvas

0

Ntaios

103

0.42 (0.03)

0.00

[−0.01; 0]

24.3

Seal 1

0

      

Seal 2

0

      

Pooled estimate (I2 = 0%)

200

 

0.00

[0; 0.01]

100

Pooled estimate (I2 = 0%)

923

 

0.00

[−0.01; 0]

100

MCV (fL)

Dangour

156

88.5 (4.3)

0.46

[−0.47; 1.40]

48.0

Durga

802

91.2 (5.1)

−0.31

[−0.80; 0.18]

83.1

Favrat

45

92.1 (7.4)

−0.56

[−2.36; 1.25]

12.9

Pathansali

0

Hvas

137

91.1 (6.3)

−0.21

[−1.24; 0.83]

39.1

Ntaios

103

91.5 (5.1)

−0.67

[−1.75; 0.42]

16.9

Seal 1

0

      

Seal 2

0

      

Pooled estimate (I2 = 0%)

338

 

0.07

[−0.58; 0.72]

100

Pooled estimate (I2 = 0%)

905

 

−0.37

[−0.82; 0.08]

100

RBC (x 10−12/L)

Dangour

155

4.6 (0.4)

−0.01

[−0.08; 0.07]

77.1

Durga

802

4.8 (0.4)

−0.01

[−0.04; 0.03]

93.9

Favrat

45

4.4 (0.5)

0.02

[−0.11; 0.15]

22.9

Pathansali

0

Hvas

0

Ntaios

103

4.6 (0.4)

−0.14

[−0.28; −0.01]

6.1

Seal 1

0

      

Seal 2

0

      

Pooled estimate (I2 = 0%)

200

 

0.00

[−0.06; 0.06]

100

Pooled estimate (I2 = 72%)

905

 

−0.02

[−0.05; 0,02]

100

  1. Data are presented as the pooled difference in means (95% confidence interval) in the change in outcome parameter between baseline and follow-up (i.e., follow-up minus baseline) between the active treatment group and placebo group