Table 3 Effect of vitamin B12 and folic acid supplementation on haematological parameters
Vitamin B12 | Folic acid | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Outcome | N | Mean baseline (SD) | Mean difference | [95% CI] | Weight (%) | N | Mean baseline (SD) | Mean difference | [95% CI] | Weight (%) | ||
Haemoglobin (g/dL) | Dangour | 155 | 13.9 (1.2) | −0.01 | [−0.26; 0.25] | 51.9 | Durga | 802 | 14.3 (1.1) | −0.07 | [−0.18; 0.04] | 83.2 |
Favrat | 0 | – | – | – | – | Pathansali | 24 | 13.1 (0.9) | 0.00 | [−0.47; 0.47] | 4.6 | |
Hvas | 137 | 13.3 (1.3) | 0.01 | [−0.27; 0.29] | 41.6 | Ntaios | 103 | 14.0 (1.0) | −0.22 | [−0.51; 0.07] | 12.3 | |
Seal 1 | 25 | 12.8 (1.4) | 0.20 | [−0.65; 1.05 | 4.6 | |||||||
Seal 2 | 26 | 13.2 (1.5) | −0.62 | [−1.97; 0.72] | 1.9 | |||||||
Pooled estimate (I2 = 0%) | 343 | 0.00 | [−0.19; 0.18] | 100 | Pooled estimate (I2 = 0%) | 929 | −0.09 | [−0.19; 0.01] | 100 | |||
Haematocrit (fraction) | Dangour | 155 | 0.41 (0.03) | 0.00 | [−0.01; 0.01] | 77.0 | Durga | 802 | 0.44 (0.04) | 0.00 | [−0.01; 0] | 70.0 |
Favrat | 45 | 0.40 (0.04) | 0.00 | [−0.01; 0.01] | 23.0 | Pathansali | 18 | 0.40 (0.02) | 0.00 | [−0.01; 0.02] | 5.6 | |
Hvas | 0 | – | – | – | – | Ntaios | 103 | 0.42 (0.03) | 0.00 | [−0.01; 0] | 24.3 | |
Seal 1 | 0 | – | – | – | – | |||||||
Seal 2 | 0 | – | – | – | – | |||||||
Pooled estimate (I2 = 0%) | 200 | 0.00 | [0; 0.01] | 100 | Pooled estimate (I2 = 0%) | 923 | 0.00 | [−0.01; 0] | 100 | |||
MCV (fL) | Dangour | 156 | 88.5 (4.3) | 0.46 | [−0.47; 1.40] | 48.0 | Durga | 802 | 91.2 (5.1) | −0.31 | [−0.80; 0.18] | 83.1 |
Favrat | 45 | 92.1 (7.4) | −0.56 | [−2.36; 1.25] | 12.9 | Pathansali | 0 | – | – | − | − | |
Hvas | 137 | 91.1 (6.3) | −0.21 | [−1.24; 0.83] | 39.1 | Ntaios | 103 | 91.5 (5.1) | −0.67 | [−1.75; 0.42] | 16.9 | |
Seal 1 | 0 | – | – | – | – | |||||||
Seal 2 | 0 | – | – | – | – | |||||||
Pooled estimate (I2 = 0%) | 338 | 0.07 | [−0.58; 0.72] | 100 | Pooled estimate (I2 = 0%) | 905 | −0.37 | [−0.82; 0.08] | 100 | |||
RBC (x 10−12/L) | Dangour | 155 | 4.6 (0.4) | −0.01 | [−0.08; 0.07] | 77.1 | Durga | 802 | 4.8 (0.4) | −0.01 | [−0.04; 0.03] | 93.9 |
Favrat | 45 | 4.4 (0.5) | 0.02 | [−0.11; 0.15] | 22.9 | Pathansali | 0 | – | – | – | – | |
Hvas | 0 | – | – | – | – | Ntaios | 103 | 4.6 (0.4) | −0.14 | [−0.28; −0.01] | 6.1 | |
Seal 1 | 0 | – | – | – | – | |||||||
Seal 2 | 0 | – | – | – | – | |||||||
Pooled estimate (I2 = 0%) | 200 | 0.00 | [−0.06; 0.06] | 100 | Pooled estimate (I2 = 72%) | 905 | −0.02 | [−0.05; 0,02] | 100 | |||