We have read with great interest the article entitled “Assessments of Vessel Density and Foveal Avascular Zone Metrics in Multiple Sclerosis: An Optical Coherence Tomography Angiography Study” by Yilmaz et al. [1]. They reported that vessel densities (VD) of both macular and peripapillary areas were reduced in multiple sclerosis (MS) patients, but the foveal avascular zone (FAZ) metrics (area, perimeter and circularity index-CI-) did not significantly differ between the MS and healthy groups.

We have just analyzed the OCT results yielded by Cirrus AngioPlex (Carl Zeiss Mediatec, Dublin, CA, USA) in 12 MS patients with monocular optic neuritis recruited before COVID pandemic. Similar to Yilmaz et al. [1]. the VDs were significantly reduced in comparison with 12 healthy controls matched by age and gender, and the mean area and perimeter of FAZ did not differ between MS and controls. By contrast, the mean CI of FAZ was significantly reduced in the MS (0.68 ± 0.06) compared to controls (0.73 ± 0.06; p = 0.012) despite the small size sample.

Log in or create a free account to read this content

Gain free access to this article, as well as selected content from this journal and more on nature.com

Access through your institution

or

Sign in or create an account
Continue with Google
Continue with ORCiD