Table 3 Treatment outcomes and follow-up.

From: Hard-flaccid syndrome: a systematic review of aetiopathophysiology, clinical presentation and management

Author, year

Medications

Li-SWT

Physical therapy

Other

Duration (months)

Outcomes

Pang et al. [15]

5 mg Tadalafil, Diclofenac as required, anti-depressants (mirtazapine 15–30 mg once daily, quetiapine 50 mg daily), zopiclone 7.5 mg once daily

Not performed

Not performed

Not performed

1

Improvement in symptoms

 

Wuling anxiolytics 330 mg 3× daily

Not performed

Not performed

Not performed

2

Improvement in symptoms. IPSS decreased to 0; NIH-CPSI decreased to 2; VAS, EHS, IIEF-5, HADS did not differ significantly compared to baseline

Gul et al. [2]

5 mg Tadalafil

NR

NR

NR

2

No improvement in symptoms

 

5 mg Tadalafil

6 sessions (3600 shocks, 3 Hz, 0.13mJ/mm2)

NR

NR

6

Initial improvement in penile hardness

 

5 mg Tadalafil, 50 mg Sildenafil

NR

NR

NR

NR

Some benefit in erections

 

50 mg Sildenafil

NR

NR

NR

NR

No improvement in erections

Nico et al. [9]

NR

NR

Pelvic floor PT

NR

NR

Symptom free

Sullivan et al. [17]

91% had/using PDE5i, 45% using anxiolytics or anti-depressants

NR

NR

NR

NR

NR

Goldstein and Komisaruk, [4]

NR

NR

Pelvic floor PT

Sex therapy, left transforaminal epidural spinal injection. Later, left L5-S1 lumbar endoscopic interlaminar discectomy

12

Transient response after epidural injection. Improved erections and penile/glans sensation and reduction in HFS symptoms after discectomy

Billis et al. [8]

5 mg Tadalafil

NR

5 PT within 3-months

Psychological: pain management and coping strategies; Psychosocial: lifestyle and stress-release modifications

3

85% improvement, absent perineal and penile pain/stiffness, IIEF-5: 22 (normal), HADS-A: 7, HADS-D: 6, improved pelvic floor muscle mobility on USS

Yazar et al. [7]

5 mg Tadalafil

6 sessions

PT 1-2× weekly over 10-12w

NR

24

Symptom free

Goldstein, [16]

NR

NR

NR

NR

NR

NR

  1. EHS erectile hardness score, HFS hard-flaccid syndrome, HADS hospital anxiety and depression scale, IIEF-5 international index for erectile function-5, IPSS international prostate symptom score, LH luteinizing hormone, Li-SWT low-intensity shock wave therapy, NIH-CPSI national institutes of health chronic prostatitis symptom index, NR not reported, NSAID non-steroidal anti-inflammatory drugs, PT physical therapy, USS ultrasound scan, VAS visual analogue scale.