Abstract
After its first introduction in 1982, studies have shown that performing inflatable penile prosthesis (IPP) under local anesthesia (LA) is not only feasible but additionally provides postoperative analgesia. In our retrospective review of 1334 first-time IPP under LA between 2014 and 2024, mean injected volume of anesthetic drug was 36.5 mL. Additional conscious sedation was required in 433 patients (31.7%), and none underwent conversion to regional or general anesthesia intraoperatively. Notably, all ectopic reservoir placement (n = 184) required additional conscious sedation. Mild local anesthesia systemic toxicity (LAST) was reported in 82 cases (6.2%) which was managed with conservative treatment. In 2 patients who experienced moderate LAST, IV benzodiazepine neutralized the neurologic symptoms. Two stages of an injection was done with 1:1 mixture of 1% lidocaine and 0.75% ropivacaine through a 10 mL syringe with a 25 G 1.5-inch needle. LA also seems to provide better postoperative pain control by continuation of analgesia beyond normal half-life of the injected drugs. It also gives valuable prompts for individualized pain management post operatively. Finally, it may help detection of an intraoperative complication by utilizing sudden pain as a safety marker.
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All authors (SHP, BLA, SKW) have made substantial contributions to this work. All authors (SHP, BLA, SKW) were involved in the acquisition, analysis, and interpretation of data for the work, and all contributed to drafting the manuscript and revised it critically for important intellectual content including final approval of the version to be published. All authors (SHP, BLA, SKW) agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
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SHP: None. BLA: None. SKW: International Medical Devices, Rigicon, Uramix.
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Park, S.H., Atwater, B.L. & Wilson, S.K. First time inflatable penile prostheses performed under local anesthesia: a single surgeon series suggests ways to improve both the patient and surgeon experience. Int J Impot Res (2025). https://doi.org/10.1038/s41443-025-01129-z
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DOI: https://doi.org/10.1038/s41443-025-01129-z


