Fig. 3: Global changes in contact domain at ESEs and their target genes.
From: A DNA tumor virus globally reprograms host 3D genome architecture to achieve immortal growth
a Normalized Hi-C contact frequencies for RBLs (orange triangle) and LCLs (teal triangle) at 2 representative loci are shown on top. Left: Chromosome 1, 116 Mb to 118 Mb. Right: Chromosome 10, 124.5 Mb to 125.5 Mb. Visible changes in LCL domains are traced out in black, and RNA-seq tracks for RBL after EBV infection are shown at the bottom. Heatmaps are colored based on normalized interaction frequencies at 10 kb resolution. b Cumulative DLR values at 25 kb resolution near TSSs of genes regulated by EBV Super Enhancers (ESEs, solid lines) and all annotated genes (dotted lines) in both RBLs (orange) and LCLs (teal).
