Fig. 6: EBNA3A inactivation reduces ESEs loopings.
From: A DNA tumor virus globally reprograms host 3D genome architecture to achieve immortal growth
a Inactivation of EBNA3A resulted in significantly less interactions between ESEs at chromosome 10 (BUB3, left) and chromosome 1 (ATP1A1 and CD58, right) and their direct target genes. HiChIP links with filter threshold >3 are shown. Black arrows indicate different CTCF binding pattern in RBLs and LCLs. b Cis-chromosomal loops were visualized using Circos plots, originating from two ESEs. The cis-chromosomal loops in EBNA3A On (left) are decreased upon EBNA3A inactivation (right).
