Fig. 2: Ligand effects for Cu-mediated C–H alkynylation of ferrocenes.
From: Cu-mediated enantioselective C–H alkynylation of ferrocenes with chiral BINOL ligands
Reaction conditions: 1 (37.4 mg, 0.1 mmol, 1.0 equiv), 2a (27.5 μL, 0.25 mmol), CuOAc (18.4 mg, 0.15 mmol), Ligand (40 mol%), NaOAc (8.2 mg, 0.1 mmol), DMSO (5.0 mL), 70 °C, air, 12 h. The yield was determined using tetrachloroethane as the internal standard, and the ratio of mono/di was determined by analysis of the crude 1H NMR. The data in the bracket indicates the isolated yield.
