Fig. 2: Cryo-EM structures of hTRPV1SAF312 and hTRPV1SAF312-2.
From: Structural basis of TRPV1 inhibition by SAF312 and cholesterol
a The cryo-EM map of hTRPV1SAF312 illustrates the binding of SAF312 and CHL to hTRPV1. The SAF312 map is represented in magenta, and the CHL map is depicted in cyan. b The overall structure model of hTRPV1SAF312 is viewed parallel to the membrane. SAF312 and CHL bind to the VBP pocket. c SAF312 and CHL bind to the VBP pocket. d The cryo-EM map of hTRPV1SAF312-2 illustrates the binding of SAF312 and CHL to hTRPV1. The SAF312 map is represented in magenta, and the CHL map is depicted in orange.
