Fig. 5: Inhibition mechanism of SAF312 for hTRPV1.
From: Structural basis of TRPV1 inhibition by SAF312 and cholesterol
a From top to bottom, the VBP from hTRPV1SAF312 (wheat), the ion-conduction pore of TRPV1 calculated with HOLE is shown as the white sphere when SAF312 ligand bond, and a closeup view showing distances between R557 and E570 when SAF312 bond. b From top to bottom, the VBP from TRPV1PI PDB:7L2P (gray), the ion-conduction pore of TRPV1 calculated with HOLE is shown as the white sphere when PI bond, and a closeup view showing distances between R557 and E570 when PI bond. c From top to bottom, the VBP from TRPV1RTX/DkTX PDB:5IRX(pink), the ion-conduction pore of TRPV1 calculated with HOLE is shown as the white sphere when RTX/DkTX bond, and closeup view showing distances between R557 and E570 when RTX/DkTX bond. d From top to bottom, the VBP from TRPV1SB-3667791 PDB:8GFA (marine), the ion-conduction pore of TRPV1 calculated with HOLE is shown as the white sphere when SB-3667791 bond, and a closeup view showing distances between R557 and E570 when SB-3667791 bond.
