Fig. 3: Evaluation of the substrate scope of alkylamines. | Nature Communications

Fig. 3: Evaluation of the substrate scope of alkylamines.

From: Enantioconvergent synthesis of axially chiral amides enabled by Pd-catalyzed dynamic kinetic asymmetric aminocarbonylation

Fig. 3

All reactions were performed in DME (0.5 mL), at 50 °C for 18 h in the presence of racemic heterobiaryl triflate 1a (0.1 mmol), alkylamine (0.3 mmol), Pd(acac)2 (0.0075 mmol), Cs2CO3 (0.3 mmol), (R, SFc)-L6 (0.012 mmol) and CO (10 bar). The yields were isolated yields for all products by column chromatography, and the ee was determined by HPLC using a chiral column. aTHF/DMA (0.5 mL/0.05 mL) were used instead of DME. THF = tetrahydrofuran, DMA = N, N-dimethylacetamide, DME = 1, 2-dimethoxyethane.

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