Fig. 4: Evaluation of the substrate scope of heterobiaryl triflates. | Nature Communications

Fig. 4: Evaluation of the substrate scope of heterobiaryl triflates.

From: Enantioconvergent synthesis of axially chiral amides enabled by Pd-catalyzed dynamic kinetic asymmetric aminocarbonylation

Fig. 4

All reactions were performed in DME (0.5 mL), at 50 °C for 18 h in the presence of racemic heterobiaryl triflate 1a (0.1 mmol), 3b (0.3 mmol), Pd(acac)2 (0.0075 mmol), Cs2CO3 (0.3 mmol), (R, SFc)-L6 (0.012 mmol) and CO (10 bar). The yields were isolated yields for all products by column chromatography, and the ee was determined by HPLC using a chiral column. aFrom substrate 1 h. bFrom substrate 1i. cFrom substrate 1j. dFrom substrate 1 s.

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