Fig. 4: The protomer extracellular pore blooming-like open.
From: Activation mechanisms of dimeric mechanosensitive OSCA/TMEM63 channels
a Superimposed side view of M0 (rotate around 3°), M3a (kink around 21°), M4a (kink around 23°), M5a (kink around 75°) and M6a (kink around 33°) deformation from wildtype OSCA1.1 in closed state (purple) to OSCA1.1-F516A in non-conducting state 1 (orange). The protomer is shown as a gray surface. b Superimposed side view of M0 (rotate around 2°), M3a (kink around 68°), M4a (kink around 28°), M5a (kink around 9°) and M6a (kink around 5°) deformation from OSCA1.1-F516A in non-conducting state 1 (orange) to OSCA1.1-F516A in non-conducting state 2 (pink). The view is the same as in a, except the view of M4a, getting rotated to show the bend angle clearly. c Superimposed side view of M0 (rotate around 1°), M3a (kink around 3°), M4a (kink around 10°), M5a (kink around 34°) and M6a (kink around 20°) deformation from OSCA1.1-F516A in non-conducting state 2 (pink) to OSCA1.1-F516A in conducting state (cyan). d Superimposed side view of M0 (rotate around 6°), M3a (kink around 75°), M4a (kink around 34°), M5a (kink around 79°) and M6a (kink around 46°) deformation from wildtype OSCA1.1 in closed state (purple) to OSCA1.1-F516A in conducting state (cyan).
