Fig. 8: Proposed full activation model of the dimeric OSCA1.1 channel by mechanical force.
From: Activation mechanisms of dimeric mechanosensitive OSCA/TMEM63 channels
a, b The full activation model of the OSCA channel is shown in the cartoon. Force or high-osmolality shock may cause thinning of the local membrane, which may induce transmembrane helices deformation, and then the two OSCA protomers draw close. The interface lipid dissociated from the central cavity, and pore lipids are dislocated to the local membrane (a). Consequently, each monomeric pore undergoes a blooming-like opening of the extracellular pore and opening of the intracellular pore by upward movement of M6b (b).
