Table 1 Variation of reaction parameters


Entry	Deviation from standard conditions	Yield of 3a (%)^a	ee (%)^†
1	none	85 (83)	92
2	NiBr₂∙dme instead of NiI₂·xH₂O	33	88
3	Ni(cod)₂ instead of NiI₂·xH₂O	trace	–
4	L1a^a instead of L1^a	34	69
5	L1b^a instead of L1^a	58	5
6	L2^a instead of L1^a	26	0
7	DMMS instead of DEMS	66	92
8	w/o KI	72	93
9	NaI instead of KI	71	91
10	w/o TBAF	7	6
11	Na₃PO₄ instead of TBAF	76	92
12	NaF (1 equiv) instead of TBAF	82	91
13	THF instead of DMA	40	77
14	0 °C	53	94

^aYields were determined by gas chromatography (GC) using n-dodecane as the internal standard, the yield within parentheses is the isolated yield and is an average of two runs (0.20 mmol scale).
^†Enantioselectivities were determined by HPLC analysis.
PMP para-methoxy phenyl, DEMS diethoxymethylsilane, DMMS dimethoxymethylsilane, DMA N,N′-dimethylacetamide, TBAF tetrabutylammonium fluoride.

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