Fig. 4: High heterogeneity between brain regions during gene drive spread.
From: Viral gene drive spread during herpes simplex virus 1 infection in mice
a Infection routes following ocular inoculation of HSV-1. Male and female Balb/c mice were co-infected with 106 PFU of WT + GD in the left eye, with a starting proportion of gene drive virus of 15%. b Viral titers over time. Black lines indicate the median. n.d.: non-detected. c, d Proportion of gene drive viruses over time. Data show the average and SEM between biological replicates. e Heatmap summarizing panels (b and c). n = 4 mice for day 2 and 3, n = 6 mice for day 4. Source data are provided as a Source Data file.
