Fig. 7: MG01 prevents ataxia defect in MPS I and MPS VII mice.

A Schematic depicting the experimental design of adult (MPS I: P60; MPS VII: P90) and juvenile (P21) MG01 transplantation in MPS I and MPS VII mouse models. B Hindlimb clasping scores at 5- or 8-months post-treatment in juvenile MPS I mice. C Hindlimb clasping scores at 1-, 2- and 5-months post-treatment in adult MPS VII mice. D Hindlimb clasping scores at 1-month post-treatment in juvenile MPS VII mice. Graphs denote median. Significance was tested using a Kruskal-Wallis test followed by a Conover-Iman post hoc test. Data points in B–D represent individual animals. (n.s.: not significant, *p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001, ****p ≤ 0.0001). Panel A was in part created with BioRender.com released under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International license.