Fig. 6: Analyses of changes in histone mark patterns between CM- and EM-derived CAR-T reveal potential regulators of differences between CAR-T types that are not apparent from the transcriptome. | Nature Communications

Fig. 6: Analyses of changes in histone mark patterns between CM- and EM-derived CAR-T reveal potential regulators of differences between CAR-T types that are not apparent from the transcriptome.

From: Histone marks identify novel transcription factors that parse CAR-T subset-of-origin, clinical potential and expansion

Fig. 6: Analyses of changes in histone mark patterns between CM- and EM-derived CAR-T reveal potential regulators of differences between CAR-T types that are not apparent from the transcriptome.

A, B Heatmaps of the numbers of genes within each histone mark pattern (H3K4me2 = K4m2; H3K27me3 = K27m3) when comparing central memory (CM)- and effector memory (EM)-derived CAR-T within RNAhi (A) and RNAlo (B) genes. C, D Comprehensive gene ontology analysis by Metascape.org of RNAhi genes with histone mark patterns indicative of EM-derived CAR-T (C, red box in A) or histone mark patterns indicative of CM-derived CAR-T (D, white box in A). E–H TRRUST analysis from Metascape.org denoting transcription factors and DNA binding proteins that regulate RNAhi (E & F) and RNAlo (G & H) genes within histone mark patterns indicative of EM-derived CAR-T (E & G) or CM-derived CAR-T (F & H). Displayed P value adjusted by Benjamini-Hochberg procedure.

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