Table 1 Characteristics of Eligible Subjects

		Entire cohort		LS carriers		non-LS carriers		p value
		N	%	N	%	N	%	p value
Demography
Number of participants		217,824		615		217,209
Number of participants with medical records		162,970		457		162,513
^‡Gender: Female (Male)		100,697 (62,300)	62% (38%)	268 (189)	59% (41%)	100,408 (62105)	62% (38%)	1.676e-01
Median age (95% CI)		60 (60.0–60.0)		59 (57.0–62.0)		60 (60.0–60.0)		5.981e-01
Race	White	97,411	60%	303	66%	97,108	60%	4.363e-03
	Black	30,132	18%	63	14%	30,069	19%	9.491e-03
	Asian	4573	3%	^a		^a
	Others	3953	2%	^a		^a
	Unknown	26,901	17%	67	15%	26,834	17%	2.871e-01
Ethnicity	Hispanic	30,499	19%	73	16%	30,426	19%	1.325e-01
	Not Hispanic	132,471	81%	384	84%	132,087	81%	1.325e-01
Personal cancer history
LS-associated cancers		9368	6%	90	20%	9278	6%	p < 0.0001
	1	8343 (64, 7–105)^¶	5%	66 (60, 23–77)	14%	8277 (64, 7–105)	5%	p < 0.0001
	2	894 (64, 19–93)^¶	0.5%	^a		^a
	3+	131 (62, 23–90)^¶	0.08%	^a		^a
LS-associated cancers by type
	colorectal	2056	1%	47	10%	2009	1%	p < 0.0001
	endometrial^§	982	1%	25	5%	957	1%	p < 0.0001
	other	7509	5%	52	11%	7457	5%	p < 0.0001
non-LS-associated cancers		15,959	10%	37	8%	15922	10%	2.530e-01
No cancer		137,643	84%	330	72%	137,313	84%	p < 0.0001
Family history
Participants reported family health history		81,458	50%	237	52%	81221	50%
Participants reported family		27,642	34%^#	112	47%^#	27530	34%^#	p < 0.0001
history of LS-associated cancers
Participants with LS-associated cancers		2141	8%**	34	30%**	2107	8%**	p < 0.0001
reported family history LS-associated cancers

Others in demography includes “More than one population”, “Middle Eastern or North African”, and “Native Hawaiian or Other Pacific Islander”; Other in personal cancer history includes stomach, small intestine, ovarian, hepatobiliary, urothelial/bladder, prostate, and pancreas.
The percentage represents the proportion of that specific group within the total number of participants who have medical records except values denoted with ^# and ^**.
^aCounts suppressed per the All of Us Data and Statistics Dissemination Policy; ^#among those participants who reported family health history; ^**among those participants with family history of LS-associated cancers; ^‡Sex distribution for LS carriers: Female/Male/Unknown 266/186/5 (58%/41%/1%), and for non-LS carriers: 99710/61468/1335 (61%/38%/1%); ¶(median age at diagnosis, age range); §uterine/endometrial cancer.
p values are based on two-sided z-test for demography section and chi-square test for personal cancer history and family history sections. For comparing ages, we used the Mann-Whitney U test.

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