Fig. 1: The neutralizing anti-Hla response is a vaccine target early in life. | Nature Communications

Fig. 1: The neutralizing anti-Hla response is a vaccine target early in life.

From: Enhanced Staphylococcus aureus protection by uncoupling of the α-toxin-ADAM10 interaction during murine neonatal vaccination

Fig. 1

a Half-maximal effective concentration of anti-Hla reactive antibodies in sera from children within the designated age groups (Log EC50). b Serum-based protection against Hla-mediated (2 nM) rRBC lysis. Protection noted as percent compared to toxin-only control. For a, b, 75th and 25th (black) and 50th (red) percentiles noted. Data were analyzed by one-way ANOVA with Tukey’s multiple comparisons test. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001. Source data are provided as a Source Data file.

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