Fig. 6: HlaHRE vaccine formulation influences the TFH response. | Nature Communications

Fig. 6: HlaHRE vaccine formulation influences the TFH response.

From: Enhanced Staphylococcus aureus protection by uncoupling of the α-toxin-ADAM10 interaction during murine neonatal vaccination

Fig. 6

a Inverse correlation of TFH cell recovery and clinical abscess size from immunized mice after S. aureus SSTI infection. b Direct correlation between the anti-Hla neutralizing IC50 and TFH response from immunized mice after S. aureus SSTI infection. All mice were subjected to priming immunization as neonates with a boost at the time of weaning. Data represents the mean of biological replicates (n = 7 per group for TFH cell analysis and Alum-HlaHRE n = 11, AddaS03-HlaHRE n = 10, and n = 12 for MPLA+Alum-HlaHRE and CpG-ODN1585-HlaHRE groups). Data and R2 values were analyzed by non-linear regression, semi-log line. Source data are provided as a Source Data file.

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