Fig. 1: Evolution of JN.1. | Nature Communications

Fig. 1: Evolution of JN.1.

From: Lineage-specific pathogenicity, immune evasion, and virological features of SARS-CoV-2 BA.2.86/JN.1 and EG.5.1/HK.3

Fig. 1

a A representative phylogenetic tree of SARS-CoV-2 from September 1, 2023, to March 1, 2024. Pre-Omicron variants are labeled as other variants. b Step-wise accumulation of key spike mutations in Omicron XBB.1, EG.5.1, HK.3, BA.2.86, and JN.1 compared to BA.2. Key mutations are color barcoded, and represented as colored bars when present or white bars if absent. Different amino acids are shown in colored bars. The number of key mutations of each variant is summarized at the top. Mutation events are labeled on arrows. R493Q is a reversion mutation. c Summary of the spike mutations of SARS-CoV-2 lineages BA.2*, BA.2.86*, JN.1*, XBB.1*, EG.5.1*, and HK.3* compared to the ancestral SARS-CoV-2 spike protein. Color represents the proportion of each mutation in each variant. d Variant dynamics of Omicron lineages BA.2*, BA.2.86*, JN.1*, XBB.1*, EG.5.1*, and HK.3* worldwide and in different regions in terms of variant frequency. The genome data from September 1, 2023, to March 1, 2024 were analyzed. Note that BA.2* excludes BA.2.86*, XBB.1* does not include EG.5.1*, EG.5.1* does not include HK.3*, and BA.2.86* does not include JN.1* for sequence and mutation analysis.

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