Fig. 7: Schematic model of ASI-RIM neuron axis coordinating the systemic mitochondrial stress response via TGF-β/DAF-7 signaling. | Nature Communications

Fig. 7: Schematic model of ASI-RIM neuron axis coordinating the systemic mitochondrial stress response via TGF-β/DAF-7 signaling.

From: ASI-RIM neuronal axis regulates systemic mitochondrial stress response via TGF-β signaling cascade

Fig. 7: Schematic model of ASI-RIM neuron axis coordinating the systemic mitochondrial stress response via TGF-β/DAF-7 signaling.

Neuronal mitochondrial stress initiated a TGF-β signaling cascade of ASI sensory neurons and RIM interneurons axis that ensure cell non-autonomous UPRmt induction in peripheral tissues. ASI-specific neuronal mitochondrial stress induced cell non-autonomous UPRmt which was mediated by dopamine and negatively regulated by GABA, confer increased lifespan, enhanced pathogen tolerance, fat storage depletion, and various physiological changes. Created in BioRender. Wang, Z. (2023) BioRender.com/h64v432.

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